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Unlabelled: Mowat-Wilson Syndrome (MWS) is a multiple congenital anomaly syndrome caused by mutations in the which plays a critical role in cell fate determination and differentiation during development. Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported in MWS patients. However, the role of ZEB2 in urinary tract development and the cellular and molecular mechanism underlining the CAKUT phenotypes in MWS remains unknown.
View Article and Find Full Text PDFHot and Cold Fibrosis: The Role of Serum Biomarkers to assess the Immune Mechanisms and ECM-Cell Interactions in Human Fibrosis.
J Hepatol
March 2025
Nordic Bioscience A/S, Fibrosis Biology and Biomarkers, Herlev, Denmark.
Fibrosis is a pathological condition characterized by excessive accumulation of extracellular matrix (ECM) components, particularly collagens, leading to tissue scarring and organ dysfunction. In fibrosis, an imbalance between collagen synthesis (fibrogenesis) and degradation (fibrolysis) results in the deposition of fibrillar collagens disrupting the structural integrity of the ECM and, consequently, the tissue architecture. Fibrosis is associated with a wide range of chronic diseases, including liver cirrhosis, kidney fibrosis, pulmonary fibrosis, and autoimmune diseases.
View Article and Find Full Text PDFA review of physiologically based pharmacokinetic modeling of renal drug disposition.
Drug Metab Dispos
January 2025
Genentech Inc., South San Francisco, California.
The human kidney is a critical organ for the elimination of numerous drugs and metabolites. The mechanisms of renal drug handling are manifold including unbound filtration, transporter-mediated active secretion, bidirectional passive diffusion, and occasionally active reabsorption and renal metabolism. These mechanisms collectively dictate the fate of drugs at various spatiotemporal points as drug molecules travel through the renal vasculature, tubules, and cells, posing a significant challenge in accurately describing and predicting renal drug disposition.
View Article and Find Full Text PDFBiodistribution and persistence of human umbilical cord-derived mesenchymal stem cells in NCG mice: a comparative study.
Future Sci OA
December 2025
Stem Cell Biology and Regenerative Medicine Apartment, Yi-Chuang Institute of Bio-Industry, Beijing, China.
Introduction: This study aims to investigate the biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in NCG mice post-intravenous injection, utilizing Zr-PET/CT, bioluminescence imaging, multiplex immunohistochemistry (mIHC), and quantitative polymerase chain reaction (qPCR).
Methods: hUC-MSCs were labeled with Zr-oxine (Zr-MSCs) or transduced with luciferase gene (Luc-MSCs). Real-time tracking of Zr-MSCs lasted for 14-days followed by mIHC staining of hCD73.
CRISPR/Cas9-mediated generation of a homozygous CBR2 knockout H1 human embryonic stem cell line.
Stem Cell Res
February 2025
Institutes of Biomedical Sciences, Shanxi Provincial Key Laboratory for Medical Molecular Cell Biology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China. Electronic address:
Mutations in the Crumbs homolog 2 (CRB2) gene cause various autosomal recessive genetic diseases, such as leber congenital amaurosis, retinitis pigmentosa and ventriculomegaly with cystic kidney disease. However, the precise roles of CRB2 in cell fate determination remains unknown. Here, we generated a homozygous CRB2 knockout (CRB2) H1 human embryonic stem cells (hESCs) using CRISPR/Cas9 system.
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