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Efficacy and safety of avatrombopag in the treatment of chemotherapy-induced thrombocytopenia in children with acute lymphoblastic leukemia: a single-center retrospective study.
Ther Adv Hematol
December 2024
Department of Pediatrics, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, China.
Background: Chemotherapy-induced thrombocytopenia (CIT) commonly exacerbates the difficulty of cancer treatment, increasing bleeding risks and potentially reducing chemotherapy dosage, ultimately impacting its efficacy. However, there are limited studies about avatrombopag application in acute lymphoblastic leukemia (ALL) CIT.
Objectives: We aimed to evaluate the efficacy and safety of avatrombopag in treating CIT patients diagnosed with ALL.
Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation.
Health Technol Assess
December 2024
York Trials Unit, Department of Health Sciences, University of York, York, UK.
Background: Dupuytren's contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing limited fasciectomy with collagenase injection.
View Article and Find Full Text PDFComparative Analysis of Hemodynamic Effects of Remimazolam and Propofol Combined with Esketamine in Colonoscopic Procedures in the Elderly.
Drug Des Devel Ther
November 2024
Department of Anesthesia, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
Article Synopsis
- The study compares the effects of remimazolam combined with esketamine versus propofol combined with esketamine on the heart and blood pressure in elderly patients during painless colonoscopies.
- A total of 754 patients were equally divided into two groups, with results showing that those on the remimazolam-esketamine combo had significantly less hypotension and fewer heart rate issues compared to the propofol group.
- Overall, the remimazolam group demonstrated better hemodynamic stability, quicker recovery, and fewer side effects, all while achieving full sedation success.
Real-world effectiveness of COVID-19 vaccine in people with HIV compared with a matched HIV-negative cohort: A test-negative design.
Int J Infect Dis
January 2025
Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, USA; South Carolina SmartState Center for Healthcare Quality, University of South Carolina, Columbia, USA.
Objectives: We estimated vaccine effectiveness (VE) against SARS-CoV-2 infection among a statewide cohort of people with HIV (PWH) and compared the estimates with a matched cohort of people without HIV (PWoH) in South Carolina (SC), USA.
Methods: A population-based cohort was retrieved from statewide electronic health records between January 2, 2021, and April 14, 2022, during which several variants were circulating in SC (i.e.
High-dose Intravenous N-Acetylcysteine in Mechanically Ventilated Patients with COVID-19 Pneumonia: A Propensity-Score Matched Cohort Study.
J Intensive Care Med
November 2024
Intensive Care Unit, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong.
Article Synopsis
- Current severe COVID-19 treatments have side effects, and N-acetylcysteine (NAC) is being explored as a safer alternative, though research on its effectiveness in critical cases is limited.
- A study analyzed data from patients over 18 in ICU with respiratory failure and found that those receiving high-dose NAC (10 g/day) had higher 28-day mortality and fewer ventilator-free days compared to those who did not.
- After adjusting for variables, the matched analysis showed no significant impact of NAC on 28-day mortality rates or recovery metrics, suggesting it may not be an effective treatment for severe COVID-19 pneumonia.*
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