Cladophialophora bantiana (Xylohypha bantiana, Cladosporium trichoides), a dematiaceous fungus, causes mainly infections of the central nervous system. Systemic antifungal therapy is apparently unsuccessful. Extracerebral involvement is uncommon and only few cases have been reported. We describe a 63-year-old patient, a kidney transplant recipient on prolonged prednisone and cyclosporin, who developed a large single lesion on the thigh from which Cladophialophora bantiana was cultured. A 3-month course of itraconazole 200 mg daily resulted in complete healing of the lesion. To the best of our knowledge this is the first report on cutaneous infection with Cladophialophora bantiana in an organ transplant recipient and the first in whom treatment with itraconazole led to resolution.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Overview of Fungi Classified as Risk Group 3 by the Japanese Society for Medical Mycology.
Med Mycol J
December 2024
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences.
Article Synopsis
- Fungi are classified into four Risk Groups based on their potential to harm humans, with Risk Group 3 indicating significant dangers, including fatalities.
- This review highlights dangerous fungi like Blastomyces dermatitidis and Cladophialophora bantiana, which are known for severe health impacts and high mortality rates due to laboratory-acquired infections.
- Strict biosafety measures are essential in labs handling these fungi due to their associated risks and documented cases of infections and deaths.
Retraction notice to "Cladophialophora bantiana metabolites are efficient in the larvicidal and ovicidal control of Aedes aegypti, and Culex quinquefasciatus and have low toxicity in zebrafish embryo" [Sci. Total Environ. 852 (2022) 158502].
Sci Total Environ
December 2024
Laboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Ecology, Conservation, and Biodiversity, Federal University of Uberlândia, Uberlândia, MG, Brazil; Post-Graduation Program in Biotechnology and Biodiversity, Federal University of Goiás, Goiânia, GO, Brazil.
A case of disseminated autochthonous Cladophialophora bantiana infection in a renal transplant recipient in the UK.
Lancet Infect Dis
November 2024
Department of Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address:
Disease associated with Cladophialophora bantiana infection is uncommon but can be characterised by severe and life-threatening CNS involvement. Diagnosis is challenging due to both the infection's rarity and non-specific clinical presentation, which can mimic malignancy and infection caused by more common organisms. Transmission can occur via inhalation or inoculation through compromised skin, followed by haematogenous dissemination to the brain and other organs.
View Article and Find Full Text PDFReappraising Cladophialophora bantiana phaeohyphomycosis in France: retrospective nation-based study.
Lancet Microbe
November 2024
Centre Hospitalo-Universitaire Régional de Tours, Department of Parasitology-Mycology-Tropical Medicine, Tours, France. Electronic address:
Article Synopsis
- * This study analyzed cases of C bantiana infections in France and its territories, involving patients who were diagnosed through a comprehensive surveillance program, focusing on survival rates and the presence of central nervous system (CNS) involvement.
- * Out of 23 patients identified from 2002 to 2022, 65% had CNS involvement, with a notable increase in cases reported in 2022, indicating a possible correlation with environmental factors like rising temperatures.
A Rare Case of Intracranial Infection: Highlighting the Utility of Next-Generation Sequencing in Diagnosis.
Case Rep Transplant
September 2024
Division of Infectious Diseases Virginia Commonwealth University Health System, Richmond, Virginia 23298-0049, USA.
is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!