The Ca(2+)-independent K+ selective channel in the membrane of adrenal gland chromaffin granules has earlier been identified. In the present report we describe new properties of this potassium channel using 86Rb+, a K+ analogue, flux measurements. The studies are performed in membrane vesicles prepared from chromaffin granules. The electrogenic 86Rb+ transport is inhibited by quinacrine, barium, zinc and magnesium. The effects of other potassium channel blockers on 86Rb+ transport into chromaffin granules are also reported.
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| http://dx.doi.org/10.1080/15216549700201721 | DOI Listing |
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