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Serological Weak Expression of D Antigen: A Retrospective Study of Blood Donors and Patients at a Teaching Hospital in Eastern India.
Cureus
December 2024
Immunohematology and Blood Transfusion, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Background and objective RhD variants show altered D antigen expression, affecting their serological detection. Proper identification is crucial due to potential anti-D antibody formation. This study aimed to retrospectively analyze the frequency and characteristics of D variant cases encountered during RhD typing in both blood donors and recipients and the transfusion implications.
View Article and Find Full Text PDFEvaluation of the hematological parameters, inflammatory biomarkers, and thyroid hormones in hypothyroidism patients.
BMC Res Notes
December 2024
Department of Immunology, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Aim: Hypothyroidism is created by disruption of thyroid hormone production, which can destroy the emotional, relational, social, and working life of patients if left untreated. Hypothyroidism has multiple etiologies. We evaluated the relationship of hematological parameters and inflammatory biomarkers with thyroid hormones to find the potential use of these items in patients screening and prognosis.
View Article and Find Full Text PDFMaternal red blood cell alloimmunization prevalence in the United States.
Blood Adv
August 2024
Quest Diagnostics, Secaucus, NJ.
Article Synopsis
- * A study analyzing 9,876,196 pregnancies from 2010 to 2021 found that 1.5% screened positive for RBC antibodies, with anti-D being the most prevalent (64.1%) among high-risk antibodies for HDFN.
- * The incidence of high-risk antibodies increased significantly over the study period, emphasizing the need for new strategies to reduce alloimmunization and improve outcomes for pregnant individuals and newborns. *
Characterization of Novel Allele Variants and Their Implications for Routine Blood Group Diagnostics.
Biomedicines
February 2024
Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8036 Graz, Austria.
The Rh system, including the highly immunogenic D antigen, is one of the clinically most important blood group systems in transfusion medicine. Numerous alleles of the gene are associated with variant RhD phenotypes. In case of Rh incompatibility, some of them can induce hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.
View Article and Find Full Text PDFRHD-negative red cells may be avoided for patients with ambiguous serologic typing for the RHD antigen.
Transfusion
February 2024
Institute of Transfusion Medicine, University Hospital of Schleswig-Holstein, Lübeck/Kiel, Germany.
Background And Objectives: Serologic typing with monoclonal anti-D is mandatory for RHD antigen determination before transfusion, but due to aberrant (weak or partial) variants of RHD, results may be ambiguous and molecular RHD-typing is required. Before that, RHD-negative (RHD -) red blood cells concentrates (RBCs) shall be transfused to avoid anti-D formation, which probably leads to wastage of RHD - RBCs. STUDY DESIGN AND METHODS: All patients with ambiguous results in serologic RHD-typing and molecular RHD-typing were assessed retrospectively.
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