Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0022-3476(97)70264-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of the bradford hill criteria to assess the causality of cisapride-induced arrhythmia: a model for assessing causal association in pharmacovigilance.
Drug Saf
September 2007
Drug Safety Research Unit, Bursledon Hall, Southampton, UK.
Introduction: The Bradford Hill criteria are a widely used, useful tool for the assessment of biomedical causation. We have examined their application to pharmacovigilance using the example of cisapride-induced QTc interval prolongation/arrhythmia.
Methods: A literature search was conducted using MEDLINE, EMBASE, Reactions Weekly and regulatory websites to identify evidence for the association between cisapride and QTc interval prolongation/arrhythmia that had been published in the English language.
Age-dependent effects on cisapride-induced QTc prolongation in the isolated guinea pig heart.
J Pharmacol Toxicol Methods
October 2006
Procter and Gamble Pharmaceuticals, Miami Valley Innovation Center, 11810 E. Miami River Rd. Cincinnati, OH 45252, USA.
Introduction: The isolated guinea pig heart preparation has been suggested as a suitable small animal model for investigating potential for QTc prolongation. The purpose of this study was to investigate the effect of age on electrophysiological parameters measured in the isolated guinea pig heart preparation. In addition, the effect of a compound known to prolong the QT interval (cisapride) was investigated in both young and adult guinea pigs.
View Article and Find Full Text PDFIntrauterine growth retardation is a risk factor for cisapride-induced QT prolongation in preterm infants.
Cardiovasc Drugs Ther
September 2004
Department of Preventive Pediatrics and Neonatology, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
Background: Cisapride is a possible cause of potentially life threatening QT prolongation.
Aims: We investigated these cardiac side effects in premature infants, mainly in relation to fetal growth.
Patients: Forty six preterms (mean birth weight 1.
Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation.
Circulation
August 2003
Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501-1787, USA.
Background: Cisapride, a gastrointestinal prokinetic agent, was recently withdrawn from the market because of its propensity to induce torsade de pointes (TdP) arrhythmias. The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation.
Methods And Results: Transmembrane action potentials from epicardial and M regions and a pseudo-ECG were simultaneously recorded.
[Cisapride and risk of cardiac complications].
Minerva Pediatr
June 2000
Clinica Pediatrica R, P. O. Aiuto Materno, Palermo.
Cisapride is a prokinetic agent thought to be without severe side effects. Recently, rare cisapride-induced cardiotoxic effects (QT interval prolongation, ventricular arrhythmias) have been reported, raising questions about its safety. Some risk factors have been reported: overdosage of cisapride, association with some drugs inhibiting hepatic metabolism via the cytochrome P450 3A4 enzymatic system (such as azole antifungals, macrolide antibiotics, non sedating antihistamines), other pharmacological agents increasing the parasympathetic tone by raising the effect of cisapride (such as ranitidine and cimetidine), electrolyte abnormalities (such as low serum levels of calcium, potassium and magnesium in the blood), liver dysfunctions, congenital long QT syndrome, and infants born before 36 weeks' gestation, for three months after birth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!