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Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade.
Medicina (Kaunas)
December 2024
Otolaryngology Head and Neck Surgery, Department Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
: Chronic rhinosinusitis (CRS) is a complex inflammatory condition of the nasal passages that severely impairs quality of life. Type 2 CRS is characterized by eosinophilic inflammation, driven by cytokines like IL-4, IL-5, and IL-13. These cytokines are key to CRS pathogenesis and contribute to a heavy disease burden, especially with comorbidities.
View Article and Find Full Text PDFProximity of maxillary molar palatal roots to adjacent structures for endodontic microsurgery: a cone-beam computed tomography study.
BMC Oral Health
January 2025
Beijing Yakebot Technology Co., Ltd, F-616-West Building, Yonghe Plaza, No. 28 Andingmen Dongdajie, DongCheng District, Beijing, 100007, China.
Background: The surgical complexity associated with the palatal roots of maxillary molars was considerably elevated. Previous studies on the relationships between maxillary molar roots and the maxillary sinus or cortical plates have focused on individual root observation without considering the positional relationship between buccal and palatal roots or analysing the surgical pathway of maxillary molar palatal roots. This study aimed to investigate the relationship between maxillary molar palatal roots and adjacent anatomical structures to provide a reference for performing palatal roots endodontic microsurgery.
View Article and Find Full Text PDFUtilization of dupilumab in an immunocompromised patient with extensive allergic fungal rhinosinusitis unsuitable for surgical intervention: A case report.
Int J Surg Case Rep
November 2024
Department of Otolaryngology-Head & Neck, King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh, Saudi Arabia.
Article Synopsis
- Allergic fungal rhinosinusitis (AFRS) is a type of chronic rhinosinusitis linked to a hypersensitivity to fungi, particularly affecting immunocompromised individuals.
- A 32-year-old patient with a history of Wilson's disease and a liver transplant faced severe nasal obstruction and other symptoms, leading to a diagnosis of AFRS after surgery and biopsy, but risks from carotid artery dehiscence complicated further surgical interventions.
- The patient achieved complete symptom resolution after starting dupilumab, a biologic therapy, highlighting its potential as a safe and effective treatment option for high-risk patients with AFRS.
Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients.
Echocardiography
January 2025
Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Purpose: There are limited reports on the potential link between Lp(a) and ARDM. Thus, we examined the relationship between Lp(a) and ARDM among hypertensive patients.
Methods: We used echocardiography to measure ARDM in 513 consecutively hospitalized patients.
The Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative.
Pediatr Infect Dis J
October 2024
From the Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Background: When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial infections (IBIs). We sought to evaluate the change in epidemiology and relationships between specific VRIs and IBIs [complicated pneumonia, complicated sinusitis and invasive group A streptococcus (iGAS)] over time using the National COVID Cohort Collaborative (N3C) dataset.
Methods: We performed a secondary analysis of all prospectively collected pediatric (<19 years old) and adult encounters at 58 N3C institutions, stratified by era: pre-pandemic (January 1, 2018, to February 28, 2020) versus pandemic (March 1, 2020, to June 1, 2023).
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