Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1749-6632.1997.tb51671.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity.
Front Immunol
November 2024
ProLynx Inc., San Francisco, CA, United States.
Article Synopsis
- IL-15 agonists are promising immunotherapy options as they boost the growth of immune cells like natural killer (NK) and CD8 T cells, but they have a short duration in the body requiring frequent doses.
- A new approach using hydrogel microspheres (MS) was developed to extend the half-life of IL-15, which successfully increased its duration to about one week.
- The study found that the MS conjugate of another IL-15 agonist, RLI, had a shorter half-life of 30 hours and was effective in stimulating immune cells, but caused significant injection-site toxicity; thus, it was focused on for intra-tumoral therapy where such effects could be potentially beneficial.
Clinical Outcomes of Carbon Ion Radiation Therapy for Malignant Peripheral Nerve Sheath Tumors.
Adv Radiat Oncol
November 2024
Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Article Synopsis
- The study aimed to assess the effectiveness and side effects of high-dose carbon ion radiation therapy (CIRT) in treating patients with malignant peripheral nerve sheath tumors (MPNSTs), analyzing data from 23 patients treated between 2013 and 2020.
- Results showed promising overall survival rates of approximately 82% at 1 year and 61.5% at 2 years, alongside local relapse-free survival rates of 65% and 48.8% at the same intervals, with no treatment-related deaths reported.
- While some patients experienced acute (43.5%) and late (34.8%) toxicities mostly classified as grade 2 or higher, there were no severe toxicities (grade 4)
Challenges and Complications in the Management of Advanced Oropharyngeal Carcinoma: Role of Post-Mortem Diagnosis and Future Perspectives.
J Clin Med
September 2024
Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy.
Oropharyngeal squamous-cell carcinoma (OPSCC) poses significant challenges in diagnosis, treatment, and management and has important medico-legal and forensic implications. In particular, the management of OPSCC and its treatment-related complications can often be challenging. In cases with advanced OPSCC, a loco-regional extension of the tumor can contribute to the destruction of oral cavity tissues, while the radiotherapy treatment can induce profound changes in tissue morphology and structure.
View Article and Find Full Text PDFNeoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study.
Nat Commun
September 2024
Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, The Netherlands.
Neoadjuvant immune checkpoint blockade (ICB) has shown unprecedented activity in mismatch repair deficient (MMRd) colorectal cancers, but its effectiveness in MMRd endometrial cancer (EC) remains unknown. In this investigator-driven, phase I, feasibility study (NCT04262089), 10 women with MMRd EC of any grade, planned for primary surgery, received two cycles of neoadjuvant pembrolizumab (200 mg IV) every three weeks. A pathologic response (primary objective) was observed in 5/10 patients, with 2 patients showing a major pathologic response.
View Article and Find Full Text PDFIntroduction: Malignant insulinoma is a rare neuroendocrine tumor responsible for excessive insulin secretion and life-threatening hypoglycemia episodes. Computed tomography (CT) of the abdomen can identify a pancreatic tumor corresponding to insulinoma. Loco-regional metastases define the metastatic cases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!