A new analytical method using ascending paper chromatographic technique was developed for identification and quantitative determination of residual synephrine in fresh and deteriorated samples. This method was found to be stability indicating; one to five degradation products have been successfully separated from drug samples subjected to accelerated stability testing at 60 degrees C for 3 months.
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Simultaneous determination of 50 antibiotic residues in plasma by HPLC-MS/MS.
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Exposure to low doses of antibiotics in organisms may have long-term effects on host growth and brain neurochemicals, which are achieved by disrupting the composition and metabolism of gut flora. Therefore, we should pay more attention to the use and management of antibiotics to protect human health and the ecological environment. Here, we developed a method of detecting 50 antibiotic residues simultaneously in human plasma using HPLC-MS/MS.
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Mechanistic modeling of anti-Langmuirian to Langmuirian behavior of Fc-fusion proteins in cation exchange chromatography.
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Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China. Electronic address:
Development of a next-generation chromatographic model, capable of simultaneously meeting academic demands for thermodynamic consistency and industrial requirements in everyday project work, has become a focal point of research. In this study, anti-Langmuirian to Langmuirian (AL-L) elution behavior was observed in cation-exchange chromatographic separation of charge variants of industrial Fc-fusion proteins. To characterize this behavior, the multi-protein Mollerup activity model was integrated into the steric mass action (SMA) model, resulting in a new model named the generalized ion-exchange (nGIEX) isotherm for multi-protein systems.
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