AI Article Synopsis
- Naltrexone has been found effective for treating conditions like alcoholism and eating disorders, beyond its use for opiate addiction.
- Some previous studies used high doses (100-200 mg) but noted potential liver issues at even higher doses (300 mg/day).
- In a double-blind trial, researchers found no harmful effects on liver function when administering high doses of naltrexone (100 mg bid, then 200 mg bid) to patients with eating disorders.
Article Abstract
Studies have found naltrexone useful in the treatment of diseases other than opiate addiction in which endogenous opioids presumably play a role, such as alcoholism and eating disorders. Some of these studies involve high doses (100-200 mg bid). Because investigational studies with high doses (300 mg/day) reported clinically significant increases in liver enzyme levels, the authors measured a spectrum of liver function parameters in response to high doses of naltrexone in a double-blind, crossover trial (100 mg bid) followed by an open-label period (200 mg bid). They observed no adverse clinical or laboratory changes in liver function in association with high-dose naltrexone therapy in eating disorders.
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| http://dx.doi.org/10.3109/10550499708993159 | DOI Listing |
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