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Bacterial clustering biomaterials as anti-infective therapies.
Biomaterials
May 2025
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117559, Singapore. Electronic address:
In Nature, bacterial clustering by host-released peptides or nucleic acids is an evolutionarily conserved immune defense strategy employed to prevent adhesion of pathogenic microbes, which is prerequisite for most infections. Synthetic anti-adhesion strategies present as non-lethal means of targeting bacteria and may potentially be used to avoid resistance against antimicrobial therapies. From bacteria-agglutinating biomolecules discovered in nature to synthetic designs involving peptides, cationic polymers and nanoparticles, the modes of actions appear broad and unconsolidated.
View Article and Find Full Text PDFSIMpat: A Synthetic Benchmark for Similarity Metrics on Patient Representations.
Stud Health Technol Inform
August 2024
Division of Medical Information Sciences, Geneva University Hospitals, Geneva, Switzerland.
Similarity and clustering tasks based on data extracted from electronic health records on the patient level suffer from the curse of dimensionality and the lack of inter-patient data comparability. Indeed, for many health institutions, there are many more variables, and ways of expressing those variables to represent patients than patients sharing the same set of data. To lower redundancy and increase interoperability one strategy is to map data to semantic-driven representations through medical knowledge graphs such as SNOMED-CT.
View Article and Find Full Text PDFGuidelines for naming and studying plasma membrane domains in plants.
Nat Plants
August 2024
NanoSignaling Lab, Zentrum für Molekularbiologie der Pflanzen, Eberhard Karls Universität Tübingen, Tübingen, Germany.
Biological membranes play a crucial role in actively hosting, modulating and coordinating a wide range of molecular events essential for cellular function. Membranes are organized into diverse domains giving rise to dynamic molecular patchworks. However, the very definition of membrane domains has been the subject of continuous debate.
View Article and Find Full Text PDFToward a nomenclature consensus for diverse intelligent systems: Call for collaboration.
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Department of Biomedical Engineering, School of Engineering, Biomedical Imaging Center, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Disagreements about language use are common both between and within fields. Where interests require multidisciplinary collaboration or the field of research has the potential to impact society at large, it becomes critical to minimize these disagreements where possible. The development of diverse intelligent systems, regardless of the substrate (e.
View Article and Find Full Text PDFLignanamides: A comprehensive review of chemical constituents, biological activities, extraction methods and synthetic pathway.
Food Chem
December 2024
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Laboratory of Quality and Safety Risk Assessment on Agro-products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Beijing, China; Western Agricultural Research Center, Chinese Academy of Agricultural Sciences, Changji 831100, China. Electronic address:
Lignanamides are a class of compounds containing amide functional groups in lignans. These compounds have excellent anti-inflammatory and neuroprotective, which have shown great potential in terms of food additives, medicine and health supplement. We summarized the recent progress of lignanamides, including chemical constituents, extraction methods, biological activities, and synthetic pathways.
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