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Generation of effective and specific human TCRs against tumor/testis antigen NY-ESO-1 in mice with humanized T cell recognition system.
Front Immunol
January 2025
Molecular Immunology and Gene Therapy, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Generation of high avidity T cell receptors (TCRs) reactive to tumor-associated antigens (TAA) is impaired by tolerance mechanisms, which is an obstacle to effective T cell therapies for cancer treatment. NY-ESO-1, a human cancer-testis antigen, represents an attractive target for such therapies due to its broad expression in different cancer types and the restricted expression in normal tissues. Utilizing transgenic mice with a diverse human TCR repertoire, we isolated effective TCRs against NY-ESO-1 restricted to HLA-A*02:01.
View Article and Find Full Text PDFA new disease symptomology observed in wheat is associated with high levels of Triticum mosaic virus transcripts.
Plant Dis
January 2025
Colorado State University System, Soil and Crop Sciences, Fort Collins, Colorado, United States;
Wheat is an important cereal crop globally and in the United States, and is the largest crop grown by acreage in Colorado. In June 2023, we observed wheat fields displaying severe yellowing and virus-like disease symptoms in plants across seven eastern Colorado counties (Yuma, Prowers, Kit Carson, Washington, Sedgewick, Morgan, and Weld). Symptomatic plants were prominent in fields and appeared bright yellow, with ringspots, mosaic patterning, and streaking on leaves.
View Article and Find Full Text PDFHespintor Negative Regulation of PI3K/Akt Pathway Induces Cell Cycle Arrest of Hepatocellular Carcinoma.
Bull Exp Biol Med
January 2025
Department of Laboratory Medicine, Putian University, Putian, China.
The mechanism of Hespintor (a protein of serpin family) inhibitory action on the growth of inoculated hepatocellular carcinoma was studied in a model of human hepatoma in nude mice by using on long-noncoding RNA (lncRNA) sequencing. Two days after tumor transplantation, Hespintor or normal saline was injected into the caudal vein at a dose of 15 μg/kg (2 times a week over 4 weeks). The tumors were isolated in 4 weeks after subcutaneous injection of human hepatoma MHCC97-H cells.
View Article and Find Full Text PDFDetailed characterisation of the Co-Smad protein in liver fluke .
J Helminthol
January 2025
Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Fasciolosis, caused by the liver flukes and , is a zoonotic parasitic disease associated with substantial economic losses in livestock. The transforming growth factor-beta signalling pathway is implicated in developmental processes and biological functions throughout the animal kingdom, including the spp. It may also mediate host-helminth interactions during infection.
View Article and Find Full Text PDFProtocol for capturing a full transcriptome from single preimplantation embryos using So-Smart-seq.
STAR Protoc
January 2025
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:
Strand-optimized Smart-seq (So-Smart-seq) can capture a comprehensive transcriptome from low-input samples. This technique detects both polyadenylated and non-polyadenylated RNAs, inclusive of repetitive RNAs, while excluding highly abundant ribosomal RNAs. So-Smart-seq preserves strand information and minimizes 5' to 3' coverage bias.
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