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Type 2 inflammation: a Portuguese consensus using Web-Delphi and decision conferencing (INFLAT2-PT).
Expert Rev Clin Immunol
January 2025
CEGIST-Centro de Estudos de Gestão, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Objectives: Atopic/allergic diseases impose a growing burden on public health, affecting millions of patients worldwide. The main objective of this study was to develop a national expert consensus on relevant clinical questions related to type 2 inflammation.
Methods: We conducted: a comprehensive literature review with a qualitative analysis to identify the most repeated themes on the overlap of conditions; a modified 3-round Web-Delphi (or e-Delphi); and a final online decision conference.
Eosinophilic inflammation: a key player in COPD pathogenesis and progression.
Ann Med
December 2024
Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Article Synopsis
- Chronic Obstructive Pulmonary Disease (COPD) poses a major public health issue, with eosinophilic inflammation playing a key role in its progression and flare-ups.
- This review focuses on how eosinophils contribute to airway changes and the inflammatory processes in COPD, highlighting the potential for targeted therapies.
- The findings suggest that targeting eosinophils could lead to better treatment strategies, emphasizing the need for ongoing research to utilize eosinophil biomarkers in managing COPD.
Interleukin-1 type 1 receptor blockade attenuates the exaggerated exercise pressor reflex in male UC Davis type 2 diabetic mellitus rats.
J Physiol
November 2024
Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
Article Synopsis
- The study investigates how interleukin-1β (IL-1β), a pro-inflammatory cytokine, affects the exercise pressor reflex in patients with type 2 diabetes mellitus (T2DM), who also experience peripheral neuropathy.
- Results indicate that blocking IL-1 receptors reduces blood pressure and heart rate responses during exercise in T2DM rats, while activating IL-1 receptors increases these responses in healthy rats.
- The findings suggest that inflammatory cytokines like IL-1β may play a significant role in heightened blood pressure reactions to exercise in individuals with T2DM, highlighting a connection between chronic inflammation and cardiovascular responses.
High-throughput Bronchus-on-a-Chip system for modeling the human bronchus.
Sci Rep
November 2024
Mimetas BV, De Limes 7 2342DH, Oegstgeest, The Netherlands.
Article Synopsis
- Chronic airway inflammation can lead to conditions like COPD and asthma, causing issues such as goblet cell hyperplasia and obstructed airflow in chronic bronchitis.
- Traditional animal testing methods are being replaced by in vitro three-dimensional cultures, but these often miss important characteristics of the human airway structure.
- The Bronchus-on-a-Chip (BoC) system was developed to create a more accurate model of bronchial epithelium, successfully mimicking human responses to inflammation and improving the testing of chronic airway conditions.
Characteristics of Patients with COPD Initiating Budesonide/Glycopyrronium/Formoterol or Other Triple Therapies in Japan: A Real-World Healthcare Claims Database Study (MITOS-AURA).
Adv Ther
December 2024
Respiratory Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Academy House, 136 Hills Road, Cambridge, CB2 8PA, UK.
Article Synopsis
- In Japan, there are different inhaler combinations for treating chronic obstructive pulmonary disease (COPD), including single-inhaler and multiple-inhaler triple therapies, but there is limited information about how patients are actually treated in real-life scenarios.
- This study reviewed data from COPD patients in Japan from May 2018 to December 2021, categorizing them into four groups based on the triple therapy they started, including early adopters of a specific therapy and users of other available combinations.
- The findings revealed that a high percentage of patients had asthma as a comorbidity, and around 14% to 18% experienced moderate to severe exacerbations in the year before starting treatment, indicating significant healthcare resource utilization
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