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Enhanced Fluid Mixing in Microchannels Using Levitated Magnetic Microrobots: A Numerical Study.
Micromachines (Basel)
December 2024
Mechatronics Engineering Department, Yildiz Technical University, Istanbul 34349, Turkey.
The efficient mixing of fluids at microscale dimensions presents challenges due to the dominant laminar flow regime which restricts convective mixing. This study introduces a numerical analysis of a novel microrobotic mixing system with a levitated propeller robot, driven by magnetic fields, within a Y-shaped microchannel with a square cross-section (500 × 500 μm). Our research investigates the fluid mixing effectiveness facilitated by the microrobot through various levitation heights and orientations to enhance the mixing index (MI).
View Article and Find Full Text PDFA Comparative Study of the In Vitro Intestinal Permeability of Pinnatoxins and Portimine.
Mar Drugs
January 2025
Toxicology of Contaminants Unit, Fougères Laboratory, ANSES (French Agency for Food, Environmental and Occupational Health & Safety), 35306 Fougères, France.
The pinnatoxins (PnTXs) and portimines, produced by , have been detected in several countries, raising concerns for human health. Although no human poisoning from these toxins has been reported so far, they have been shown to distribute throughout the rodent body after oral administration. Therefore, we investigated the impact of PnTX analogs (PnTX-A, -E, -F, -G, and -H) and portimine (8, 16, and 32 ng/mL) on intestinal barrier integrity and their oral bioavailability using human Caco-2 cell monolayers treated for 2, 6, and 24 h.
View Article and Find Full Text PDFThe in-vitro digestibility of instant noodles: Interplay of texture, microstructure and starch structure.
Food Res Int
February 2025
Tianjin Key Laboratory of Food Science and Health, School of Medicine, NanKai University, Tianjin 300071, China. Electronic address:
Instant noodles are a worldwide food staple. However, the correlation between its production methods and nutritional characteristics remains unclear. This study aims to elucidate the effects of hydrothermal (steaming and boiling) and cooling techniques on instant noodles in-vitro digestibility.
View Article and Find Full Text PDFPlastic nanoparticle toxicity is accentuated in the immune-competent inflamed intestinal tri-culture cell model.
Nanotoxicology
January 2025
Department of Pharmaceutical Sciences & Administration, School of Pharmacy, Westbrook College of Health Professions, University of New England, Portland, Maine, USA.
Important cell-based models of intestinal inflammation have been advanced in hopes of predicting the impact of nanoparticles on disease. We sought to determine whether a high level and extended exposure of nanoplastic might result in the added intestinal inflammation caused by nanoplastic reported in a mouse model of irritable bowel disease. The cell models consist of a Transwell©-type insert with a filter membrane upon which lies a biculture monolayer of Caco-2 and HT29-MTX-E12 made up the barrier cells (apical compartment).
View Article and Find Full Text PDFDWI-Derived Sequences: Application in the Evaluation of Liver Fibrosis.
Curr Med Imaging
January 2025
Department of Radiology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou 434000, Hubei, China.
There exists a close relationship between liver fibrosis and Hepatocellular Carcinoma (HCC). Prolonged progression of liver fibrosis may ultimately lead to cirrhosis, thereby increasing the risk of developing HCC. Current research is exploring non-invasive methods for assessing liver fibrosis.
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