Carcinoma of the esophagus remains one of the most lethal of all cancers. In the past, squamous cell carcinomas accounted for over 95% of esophageal malignancies. Over the past two decades, however, there has been a dramatic increase in the incidence of adenocarcinoma arising in columnar cell-lined Barrett's mucosa, accounting for up to 34% of all esophageal cancers in some areas. This article discusses the different demographic, pathologic, therapeutic, and prognostic features of squamous cell and adenocarcinoma of the esophagus.
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Comparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma.
BMC Oral Health
January 2025
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.
View Article and Find Full Text PDFVitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy.
BMC Gastroenterol
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Department of Pediatrics, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China.
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View Article and Find Full Text PDF6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy.
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Center for Public Health Research, Medical School of Nanjing University, Nanjing, China.
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View Article and Find Full Text PDFOptimization of the intron sequences combined with the CMV promoter increases recombinant protein expression in CHO cells.
Sci Rep
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International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, China.
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View Article and Find Full Text PDFShaping epithelial tissues by stem cell mechanics in development and cancer.
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Howard Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Adult stem cells balance self-renewal and differentiation to build, maintain and repair tissues. The role of signalling pathways and transcriptional networks in controlling stem cell function has been extensively studied, but there is increasing appreciation that mechanical forces also have a crucial regulatory role. Mechanical forces, signalling pathways and transcriptional networks must be coordinated across diverse length and timescales to maintain tissue homeostasis and function.
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