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Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer.
Clin Epigenetics
November 2024
Institute for Stem Cell Biology, RWTH Aachen University Medical School, 52074, Aachen, Germany.
Background: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment and play a critical role in cancer progression. Numerous studies have identified significant molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and conducted a comprehensive analysis of their DNA methylation profiles, integrating our finding with data from studies on other cancer types.
View Article and Find Full Text PDFAMIGO2 characterizes cancer-associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes.
J Pathol
January 2025
Division of Molecular and Experimental Surgery, Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Secretomes of cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes.
View Article and Find Full Text PDFPerioperative systemic IL-6 and immune-adipose- metabolism transcription in tumour and tumour adjacent breast cancer.
Eur J Immunol
November 2024
Department of Surgery, School of Medicine, University College Cork, Cork, Ireland.
Surgical resection is the primary treatment approach for patients with breast cancer. Despite optimal multimodal treatment, metastatic recurrence remains a risk. Surgery-mediated systemic inflammation and local tissue inflammation generate an immunosuppressive and wound-healing environment that may accelerate cancer recurrence and metastasis post-operatively.
View Article and Find Full Text PDFExpression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.
Int J Mol Sci
August 2024
Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Adrenal tumors, such as adrenocortical carcinoma (ACC), adrenocortical adenoma (ACA), and pheochromocytoma (PCC) are complex diseases with unclear causes and treatments. Mitochondria and mitochondrial-derived peptides (MDPs) are crucial for cancer cell survival. The primary aim of this study was to analyze samples from different adrenal diseases, adrenocortical carcinoma, adrenocortical adenoma, and pheochromocytoma, and compare them with normal adrenal tissue to determine whether the expression levels of the mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) gene and protein vary between different types of adrenal tumors compared to healthy controls using qPCR, ELISA, and IHC methods.
View Article and Find Full Text PDFCD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis.
Front Cardiovasc Med
August 2024
Versiti Blood Research Institute, Milwaukee, WI, United States.
Visceral white adipose tissues (WAT) regulate systemic lipid metabolism and inflammation. Dysfunctional WAT drive chronic inflammation and facilitate atherosclerosis. Adipose tissue-associated macrophages (ATM) are the predominant immune cells in WAT, but their heterogeneity and phenotypes are poorly defined during atherogenesis.
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