Excessive alcohol consumption impairs T-cell-dependent immune function. Whether this impairment results from the direct inhibition of helper T (Th) cells or from inhibition of the cells that process and present antigen to Th cells is unclear. The present study examines the temporal effect of dietary alcohol on the development of delayed hypersensitivity (DTH) in C57BL/6 mice. We find that ethanol consumption just prior to and during the cognitive phase of the immune response impairs the development of a DTH response. Ethanol consumption initiated after the cognitive phase and during the effector phase of the immune response has no significant effect upon the elicitation of a DTH response. The results suggest that significant ethanol-induced impairment of DTH responses occurs during the cognitive phase of the immune response, when antigen presentation and recognition occur.
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