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A respirable HPV-L2 dry-powder vaccine with GLA as amphiphilic lubricant and immune-adjuvant.
J Control Release
December 2021
Department of Food and Drug Sciences, University of Parma, Parco Area delle Scienze Parma, Italy; Interdepartmental Center Biopharmanet-tec, University of Parma, Parco Area delle Scienze Parma, Italy. Electronic address:
Vaccines not requiring cold-chain storage/distribution and suitable for needle-free delivery are urgently needed. Pulmonary administration is one of the most promising non-parenteral routes for vaccine delivery. Through a multi-component excipient and spray-drying approach, we engineered highly respirable dry-powder vaccine particles containing a three-fold repeated peptide epitope derived from human papillomavirus (HPV16) minor capsid protein L2 displayed on Pyrococcus furious thioredoxin as antigen.
View Article and Find Full Text PDFImpact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice.
PLoS One
March 2020
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
The potential role of probiotic bacteria as adjuvants in vaccine trials led to their use as nonparenteral live mucosal vaccine vectors. Yet, interactions between these vectors, the host and the microbiome are poorly understood. This study evaluates impact of three probiotic, Lactobacillus acidophilus, vector strains, and their interactions with the host's immune response, on the gut microbiome.
View Article and Find Full Text PDFAre chitosan natural polymers suitable as adjuvant/delivery system for anti-tuberculosis vaccines?
Microb Pathog
August 2018
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Tuberculosis Reference Laboratory of Northeast-Iran, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Today, the effectiveness of the only approved tuberculosis (TB) vaccine, bacillus Calmette-Guerin (BCG), has encountered several serious problem in the control of TB infections including variable protection in adolescents and adults, the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) as well as HIV/AIDS co-infection. Various studies have shown that chitosan, a natural polymer, can serve as a potent carrier for the delivery of various hydrophilic molecules such as peptide, protein and drug agents due to some of its excellent characteristics including low toxicity, biodegradable and biocompatible properties and stability. Currently, these polysaccharide polymers have gained more attention as candidates for the adjuvant/delivery of anti-TB vaccines due to better cellular uptake, muco-adhesive characteristics, prolonged control release, persistent stimulation of the immune system, more efficient uptake by antigen processing cells (APCs), adjuvant/immunopotentiator function, and preventing antigen degradation in-vivo.
View Article and Find Full Text PDFIntranasal administration of inactivated avian influenza virus of H5N1 subtype vaccine-induced systemic immune response in chicken and mice.
Vet World
February 2018
Department of Animal Biomedical and Molecular Biology Laboratory Faculty of Veterinary Medicine Udayana University, Jl. Sesetan-Markisa 6, Denpasar 80226, Bali, Indonesia.
Aim: The need for non-parenteral administration of inactivated avian influenza virus of H5N1 subtype (AIV-H5N1) vaccine is paramount. Here, we provide preliminary data on the immune response of chicken and mice after intranasal administration of AIV-H5N1-inactivated vaccine with ISCOMS, Inmunair (INM), and combined ISCOMS and INM as an adjuvant.
Materials And Methods: The AIV isolate of A/Chicken/Denpasar/01/2004 (H5N1) was cultivated in specific pathogen-free chicken eggs and inactivated with formaldehyde.
Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review.
Iran J Basic Med Sci
February 2018
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Article Synopsis
- The study explores the need for effective tuberculosis (TB) vaccines and how polymer-based delivery systems can enhance their immunogenicity to address existing challenges in vaccine development.
- A comprehensive literature review identified 31 relevant studies that demonstrated the effectiveness of various polymeric particles, like PLGA and chitosan, in improving immune responses and offering long-lasting protection against TB in animal models.
- The findings suggest that while biodegradable polymers are more commonly used for TB vaccines, there’s a need for further research into non-biodegradable synthetic polymers as potential adjuvants.
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