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The mitochondrial citrate synthase from Tetrahymena thermophila does not form an intermediate filament.
Eur J Protistol
October 2024
Evolutionary Biochemistry Group, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Str. 10, 35043 Marburg, Germany; Center for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, Karl-von-Frisch-Str. 14, 35043 Marburg, Germany; Department of Chemistry, Philipps-University Marburg, Hans-Meerwein-Str. 4, 35043 Marburg, Germany. Electronic address:
The mitochondrial citrate synthase (mCS) purified from the ciliate Tetrahymena thermophila has been reported to form intermediate-filament-like structures during conjugation and to self-assemble into fibers when recombinantly expressed. This would represent a rare example of a tractable and recent origin of a novel cytoskeletal element. In an attempt to investigate the evolutionary emergence of this behavior, we re-investigated the ability of Tetrahymena's mCS to form filaments in vivo.
View Article and Find Full Text PDFAlveolin proteins in the Toxoplasma inner membrane complex form a highly interconnected structure that maintains parasite shape and replication.
PLoS Biol
September 2024
Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, United States of America.
Article Synopsis
- Apicomplexan parasites have specialized structures, like the inner membrane complex (IMC), that help them invade and replicate inside host cells.
- Disruption of the alveolin protein IMC6 in Toxoplasma led to morphological defects and issues with invasion and replication, but did not significantly affect motility.
- The study identified important protein-protein interactions involving IMC6, supporting the idea that the alveolin domain is crucial for maintaining the structural integrity of these parasites.
Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites.
Annu Rev Microbiol
November 2024
German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany.
Article Synopsis
- * These parasites depend on specialized cytoskeletal structures for their shape, replication, and movement across tissues, with recent research using advanced technologies providing new insights.
- * The review highlights recent findings in cytoskeletal biology of these parasites compared to typical model organisms and points out ongoing research questions, particularly involving key species that affect human health.
Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin.
Proc Natl Acad Sci U S A
February 2024
Medical Research Council Laboratory of Molecular Biology, Structural Studies Division, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
The protein crescentin is required for the crescent shape of the freshwater bacterium (). Crescentin forms a filamentous structure on the inner, concave side of the curved cells. It shares features with eukaryotic intermediate filament (IF) proteins, including the formation of static filaments based on long and parallel coiled coils, the protein's length, structural roles in cell and organelle shape determination and the presence of a coiled coil discontinuity called the "stutter.
View Article and Find Full Text PDFEssential function of alveolin IMC1g in the asexual blood stage.
mBio
October 2023
Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Infection by the parasite is responsible for the most severe form of human malaria. The asexual blood stage of the parasite, which occurs inside human red blood cells, is responsible for the symptoms of malaria and is the target of most antimalarial drugs. spp.
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