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Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study.
Epigenomics
January 2025
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P. R. China.
Aims: Atrioventricular block (AVB) is a prevalent bradyarrhythmia. This study aims to investigate the causal effects of epigenetic aging, as inferred from DNA methylation profiles on the prevalence of AVB by Mendelian randomization (MR) analysis.
Methods: Genetic instruments for epigenetic aging and AVB were obtained from genome-wide association study data in the Edinburgh DataShare and FinnGen biobanks.
Intermittent Short Atrioventricular Delay in a Dual Chamber Pacemaker During Acute Pulmonary Edema.
Ann Noninvasive Electrocardiol
January 2025
Cardiovascular Institute-Hospital Clínico San Carlos, Madrid, Spain.
We present the case of an 80-year-old female with acute pulmonary edema and a dual chamber pacemaker with intermittent short AV delays in the surface ECG after blocked premature atrial contractions (PACs). The behavior was consistent with the programmed Window of Atrial Rate Acceleration Detection (WARAD) and did not require further parameter modifications. As most cardiologists and emergency department physicians are not familiar with brand-specific algorithms, we believe that this case report will make these noncompetitive atrial pacing algorithms more accessible to non-cardiologists.
View Article and Find Full Text PDFAccelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study.
Eur Heart J
December 2024
Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands.
Background And Aims: Accelerated atrial pacing offers potential benefits for patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), compared with standard lower-rate pacing. The study investigates the relationship between atrial pacing rate and left-heart filling pressure.
Methods: Seventy-five consecutive patients undergoing catheter ablation for AF underwent assessment of mean left atrial pressure (mLAP) and atrioventricular (AV) conduction delay (PR interval) in sinus rhythm and accelerated atrial pacing with 10 bpm increments up to Wenckebach block.
Holter Monitoring Analysis of Women Infected with the Human Immunodeficiency Virus.
Curr HIV Res
January 2025
Department of Cardiology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, 100015, China.
Article Synopsis
- The study aimed to evaluate the heart health of women with HIV using Holter monitoring at Ditan Hospital.
- It analyzed data from 35 female HIV-infected patients, revealing various heart rhythm issues, with the most common being sinus rhythm and various premature beats.
- The findings highlighted that Holter monitoring can detect significant ECG abnormalities in HIV-positive patients, potentially allowing for earlier treatment interventions.
Modulation of Spontaneous Action Potential Rate by Inositol Trisphosphate in Myocytes from the Rabbit Atrioventricular Node.
Cells
August 2024
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK.
The atrioventricular node (AVN) is a key component of the cardiac conduction system and takes over pacemaking of the ventricles if the sinoatrial node fails. IP (inositol 1,4,5 phosphate) can modulate excitability of myocytes from other regions of the heart, but it is not known whether IP receptor (IP-R) activation modulates AVN cell pacemaking. Consequently, this study investigated effects of IP on spontaneous action potentials (APs) from AVN cells isolated from rabbit hearts.
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