Adjuvant treatment for failure of local radical therapy.

Adjuvant treatment is suitable where localised tumour recurrence justifies further treatment following failed radical prostatectomy. External beam radiotherapy is effective and may be enhanced by concomitant androgen deprivation therapy. Early adjuvant androgen deprivation therapy compared with 'deferred' therapy may drastically reduce morbidity and possibly increase survival in prostate cancer. A large clinical study is underway.