The fibroblast growth factor (FGF) family comprises to date 12 members, which are involved in various physiological processes throughout embryogenesis and adult life. Two novel members of the family have been identified recently (FGF11 and FGF12). Using in situ hybridization on metaphasic chromosomes, we have been able to assign FGF11 to band p12-p13 of human chromosome 17 and FGF12 to band q28 of human chromosome 3.
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FGF12: biology and function.
Differentiation
September 2024
Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland. Electronic address:
Fibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform.
View Article and Find Full Text PDFIdentification of antisense and sense RNAs of intracrine fibroblast growth factor components as novel biomarkers in colorectal cancer and in silico studies for drug and nanodrug repurposing.
Environ Res
December 2023
Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Centre, Farhikhtegan Hospital, Islamic Azad University, Tehran Medical Sciences, Tehran, Iran. Electronic address:
Introduction: Colorectal cancer (CRC) is one of the most malignant tumors and in which various efforts for screening is inconclusive.The intracrine FGF panel, the non-tyrosine kinase receptors (NTKR) FGFs and affiliated antisenses play a pivotal role in FGF signaling.The expression levels of coding and non-coding intracrine FGFs were assessed in CRC donors.
View Article and Find Full Text PDFFGF homologous factors are secreted from cells to induce FGFR-mediated anti-apoptotic response.
FASEB J
July 2023
Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
FGF homologous factors (FHFs) are the least described group of fibroblast growth factors (FGFs). The FHF subfamily consists of four proteins: FGF11, FGF12, FGF13, and FGF14. Until recently, FHFs were thought to be intracellular, non-signaling molecules, despite sharing structural and sequence similarities with other members of FGF family that can be secreted and activate cell signaling by interacting with surface receptors.
View Article and Find Full Text PDFPurification of recombinant human fibroblast growth factor 13 in E. coli and its molecular mechanism of mitogenesis.
Appl Microbiol Biotechnol
September 2019
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Fibroblast growth factor (FGF) 13, a member of the FGF11 subfamily, is a kind of intracrine protein similar to other family members including FGF11, FGF12, and FGF14. Unlike classical FGF, FGF13 exerts its bioactivities independent of fibroblast growth factor receptors (FGFRs). However, the effect of exogenous administration of FGF13 still remains further investigated.
View Article and Find Full Text PDFFGF12 is a candidate Brugada syndrome locus.
Heart Rhythm
December 2013
Departments of Medicine/Cardiology and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina.
Article Synopsis
- Less than 30% of Brugada syndrome (BrS) cases have a genetic cause, with common mutations found in genes like SCN5A and CACNA1C; researchers proposed fibroblast growth factor homologous factors (FHFs) as potential BrS contributors.
- The study focused on FGF12, confirming it as the main FHF in the human heart and searching for associated mutations in a large BrS patient group.
- A specific mutation (Q7R-FGF12) was linked to decreased Na(+) channel function, supporting its role in BrS and suggesting that FHFs may influence cardiac ion channels differently.
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