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Comparison of immune responses to respiratory syncytial virus in infancy, childhood, and adulthood using an in vitro model of human respiratory infection.
Immunohorizons
January 2025
Section of Infectious Diseases and Epidemiology, Department of Pediatrics, University of Colorado, Aurora, CO, United States.
Respiratory syncytial virus (RSV) is a major contributor to morbidity and mortality in infants. We developed an in vitro model of human respiratory infection to study cellular immune responses to RSV in infants, children, and adults. The model includes human lung epithelial A549 cells or human fetal lung fibroblasts infected with a clinical strain of RSV at a multiplicity of infection of 0.
View Article and Find Full Text PDFHost-derived Pediococcus acidilactici B49: a promising probiotic for immunomodulation and disease control in largemouth bass (Micropterus salmoides).
Fish Shellfish Immunol
January 2025
Henan Province Engineering Research Center of Aquatic Animal Disease Control, College of Fisheries, Henan Normal University, Xinxiang 453007, China.
Finding effective alternatives to antibiotics is crucial for sustainable aquaculture. Host-derived probiotics have great potential as a promising alternative to antibiotics for immune regulation and disease control in fish farming. However, limited research exists regarding the application of native probiotics in largemouth bass (Micropterus salmoides).
View Article and Find Full Text PDFLong-chain chlorinated paraffins (LCCPs) exposure causes senescence and inflammatory damage in cardiomyocytes.
J Environ Manage
January 2025
College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address:
Humans can be exposed to LCCPs through air and diet, leading to their accumulation in the body. Given the significance of understanding potential health risks, a thorough investigation into the detrimental health impacts of LCCPs is paramount. In this study, we conducted a series of experiments to investigate the effects of LCCPs on cardiomyocytes, employing techniques such as flow cytometry, western-blot, indirect immunofluorescence, and confocal microscopy.
View Article and Find Full Text PDFEarly Use of Liraglutide for the Treatment of Acute COVID-19 Infection: An Open-Label Single-Center Phase II Safety Study with Biomarker Profiling.
Infect Dis Rep
January 2025
Royal Brompton Hospital, Part of GSTT NHS Foundation Trust, London SW3 6NP, UK.
Background: Glucagon-like peptide-1 (GLP-1) agonists are an existing treatment option for patients with insulin-resistant states, which elicit further pleiotropic effects related to immune cell recruitment and vascular inflammation. GLP-1 agonists downregulate the cluster of differentiation 147 (CD147) receptor, one of several receptors for the SARS-CoV-2 spike protein that mediate viral infection of host cells.
Methods: We conducted an open-label prospective safety and tolerability study including biomarker responses of the GLP-1 agonist Liraglutide, administered for 5 days as an add-on therapy to the standard of care within 48 h of presentation in a cohort of 13 patients hospitalized with COVID-19 pneumonia.
Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium.
Brain Behav Immun Health
February 2025
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Delirium is a highly prevalent neuropsychiatric syndrome characterised by acute and fluctuating impairments in attention and cognition. Mechanisms driving delirium are poorly understood but it has been suggested that blood cytokines and chemokines cross the blood brain barrier during delirium, directly impairing brain function. It is not known whether these molecules reach higher brain levels when the blood cerebrospinal fluid barrier (BCSFB) is impaired.
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