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A preparatory cranial potential for saccadic eye movements in macaque monkeys.
bioRxiv
January 2025
Centre for Vision Research, Centre for Integrative & Applied Neuroscience, Vision: Science to Applications Program, Connected Minds, Department of Biology, York University, Toronto, ON M3J 1P3, Canada.
Response preparation is accomplished by gradual accumulation in neural activity until a threshold is reached. In humans, such a preparatory signal, referred to as the lateralized readiness potential, can be observed in the EEG over sensorimotor cortical areas before execution of a voluntary movement. Although well-described for manual movements, less is known about preparatory EEG potentials for saccadic eye movements in humans and nonhuman primates.
View Article and Find Full Text PDFStage 2 Registered Report: Propositional Thought Is Sufficient for Imaginal Extinction as Shown by Contrasting Participants With Aphantasia, Simulated Aphantasia, and Controls.
Psychophysiology
January 2025
Department of Psychology, University of Bonn, Bonn, Germany.
Imaginal exposure is a standard procedure of cognitive behavioral therapy for the treatment of anxiety and panic disorders. It is often used when in vivo exposure is not possible, too stressful for patients, or would be too expensive. The Bio-Informational Theory implies that imaginal exposure is effective because of the perceptual proximity of mental imagery to real events, whereas empirical findings suggest that propositional thought of fear stimuli (i.
View Article and Find Full Text PDFA multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients.
Epilepsy Behav
January 2025
Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Electronic address:
The objective of this study was to evaluate the effect of seletracetam (SEL), a potent modulator of synaptic vesicle glycoprotein 2A (SV2A), in patients with photoparoxysmal EEG response (PPR) to intermittent photic stimulation (IPS) as proof-of-principle of efficacy in patients with epilepsy. In this multicenter, single-blind Phase II study, adults with photosensitive epilepsy, with/without concomitant antiseizure medication therapy, underwent IPS under 3 eye conditions (at eye closure, eyes closed and eyes open) after a single oral dose of placebo (day - 1) or SEL (day 1; 0.5, 1, 2, 4, 10, or 20 mg).
View Article and Find Full Text PDFVisual simulation: Catching a glimpse of what's to come.
Curr Biol
January 2025
Faculty of Psychology and Educational Sciences, University of Coimbra, 3000-115 Coimbra, Portugal. Electronic address:
Are humans unique in using visual simulation to see beyond the 'here and now' in the mind's eye? A new study has now shown that monkeys can employ simulation to anticipate how physical events will unfold.
View Article and Find Full Text PDFA nature-immersive virtual reality intervention to support hospice family caregivers: Qualitative findings from a pilot study.
Asia Pac J Oncol Nurs
December 2024
College of Nursing, Michigan State University, East Lansing, MI, USA.
Article Synopsis
- Family caregivers (FCGs) of cancer patients in hospice face psychological challenges and decreased quality of life due to caregiving demands, signaling a need for supportive interventions.
- A virtual reality (VR) nature experience was implemented, allowing FCGs to immerse themselves in calming scenes at home, which they found to enhance relaxation and provide an escape from their caregiving stress.
- Preliminary findings indicate that the VR intervention is feasible and acceptable, suggesting it can support the emotional health of hospice FCGs, though further research with larger and more diverse groups is necessary.
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