Dysfunction of the cellular immune mechanism was found in 23 patients with persistent symptoms of brucellosis of more than one year's duration when skin tested for delayed hypersensitivity to dinitrochlorobenzene (DNCB). Eighteen patients had low normal or depressed E rosetting capacity of their lymphocytes. Anti-anergic treatment with levamisole 150 mg daily for one month and for two consecutive days each week for six months produced an exacerbation of symptoms after one to four weeks followed by complete relief from symptoms in 15 patients and partial relief in four. Vitamin A was used to potentiate the effect of levamisole in seven patients.
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Levamisole augments roxatidine's immune modulatory effects in the graft-versus-host reaction (GVHR).
Immunopharmacology
July 1992
Department of Pharmacology, University of Pretoria, South Africa.
Levamisole is known to have anti-anergic properties in immune compromised, but no or only marginal effects in immunologically competent subjects. In this study the possibility that levamisole would act as an 'immunoadjuvant' with roxatidine, a histamine H2 receptor blocker, is explored in healthy animals. Sixteen female, inbred Sprague-Dawley rats acted as lymphocyte donors and were treated for 8 days with either a roxatidine-levamisole combination, or levamisole alone, or roxatidine alone or placebo.
View Article and Find Full Text PDFLevamisole, a simple chemical, first introduced as a broad spectrum anthelmintic, is an immunotherapeutic agent with anti-anergic properties. It is the first member of a potential new class of immunologically active, probably thymomimetic compounds. The present knowledge from studies on isolated cells, experimental animals, healthy volunteers and patients with various diseases shows that levamisole behaves physiologically as a thymus hormone and restores to normal the functions of phagocytes and T-lymphocytes in compromised hosts and induces T-cell differentiation.
View Article and Find Full Text PDFA 46-year-old female, otherwise healthy, developed erythematous, pseudotumoral nodules, mainly on the hands; biopsies led to the diagnosis of Woringer-Kolopp disease. Anti-anergic chemotherapy with levamisole proved hazardous but, possibly, beneficial. Classification into benign localized, fatal generalized and intermediate disease is briefly commented upon.
View Article and Find Full Text PDFDysfunction of the cellular immune mechanism was found in 23 patients with persistent symptoms of brucellosis of more than one year's duration when skin tested for delayed hypersensitivity to dinitrochlorobenzene (DNCB). Eighteen patients had low normal or depressed E rosetting capacity of their lymphocytes. Anti-anergic treatment with levamisole 150 mg daily for one month and for two consecutive days each week for six months produced an exacerbation of symptoms after one to four weeks followed by complete relief from symptoms in 15 patients and partial relief in four.
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