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Multiple cardiac metastases from urothelial carcinoma case report.

Egypt Heart J

April 2022

Department of Cardiology, Mater Dei Hospital, Triq id-Donaturi tad-Demm, Msida, MSD2090, Malta.

Article Synopsis
  • Cardiac metastases are rare and often undiagnosed, with common sources being lung and breast cancers; however, urothelial carcinoma is a rare cause.
  • A 74-year-old man showed unusual fever spikes after surgery for urothelial carcinoma, leading to the discovery of multiple cardiac lesions via advanced imaging techniques.
  • The case underscores the rarity of urothelial carcinoma metastasizing to the heart and highlights the value of cardiac magnetic resonance imaging in diagnosing such conditions.
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Article Synopsis
  • Intravascular papillary endothelial hyperplasia (IPEH) is a rare but benign skin and subcutaneous tissue malformation, studied across 261 patients.
  • The study identified three categories of IPEH: pure (50%), mixed (46%), and extravascular (4%).
  • It was found that IPEH often tests positive for specific markers like CD31 and CD34, highlighting the need for better awareness and understanding among clinicians to accurately diagnose it.
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Article Synopsis
  • Papillary endothelial hyperplasia (PEH) is a rare tissue lesion from excess endothelial cell growth, often confused with angiosarcoma in humans and pets.
  • Two cats developed PEH at injection sites, initially misidentified as feline injection-site sarcoma and subcutaneous angiosarcoma.
  • The study highlights the importance of recognizing PEH in cats to prevent misdiagnosis and unnecessary treatments.
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Papillary endothelial hyperplasia or Masson tumor most commonly occurs within the extremities and head and neck. It is usually of intravascular type, associated with thrombus formation and organization within a preexisting vessel or vascular malformation, but rarely can be extravascular. We describe the first 2 cases of this extravascular type to occur within the ovary, one of which mimicked malignancy radiologically.

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Expression of α-Klotho protein in human thyroid cancers - an immunohistochemical study.

Endokrynol Pol

December 2019

Department of Neuroendocrinology, Interdepartmental Chair of Laboratory and Molecular Diagnostics, Medical University of Lodz, Poland.

Introduction: The α-Klotho protein was discovered as a gene controlling the process of aging, but further studies indicated that it also plays the role of a tumour suppressor. Although numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce. Our study presents the immunohistochemical investigation of α-Klotho expression in benign and malignant thyroid tumours.

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