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Neuroprotective effects of dantrolene in neurodegenerative disease: Role of inhibition of pathological inflammation.
J Anesth Transl Med
June 2024
Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neurodegenerative diseases (NDs) refer to a group of diseases in which slow, continuous cell death is the main pathogenic event in the nervous system. Most NDs are characterized by cognitive dysfunction or progressive motor dysfunction. Treatments of NDs mainly target alleviating symptoms, and most NDs do not have disease-modifying drugs.
View Article and Find Full Text PDFDantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in rats.
Psychopharmacology (Berl)
April 2023
Behavioral Neuroscience Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, DHHS, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Rationale: Hyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme cases. Current treatments such as whole-body cooling are only symptomatic and a clear need to develop pharmacological interventions exists. Dantrolene sodium, a peripheral muscle relaxant used in the treatment of malignant hyperthermia, has been proposed as potentially effective to treat MDMA-hyperthermia in emergency rooms.
View Article and Find Full Text PDFEcstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene.
Anaesthesia
September 2012
Anaesthesia Department, Sir Charles Gairdner Hospital, Perth, Western Australia.
We present the case of a 20-year-old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi-organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50 mg.kg(-1) dantrolene.
View Article and Find Full Text PDFDantrolene for the treatment of MDMA toxicity.
CJEM
September 2010
Department of Emergency Medicine, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada.
MDMA (3,4-methylenedioxymethamphetamine), popularly known as “Ecstasy,” was first introduced and patented by Merck & Co., Inc., in 1914 as an appetite suppressant.
View Article and Find Full Text PDF[Fatal ecstasy intoxication in a 22-year-old man].
Ned Tijdschr Geneeskd
July 2007
Jeroen Bosch Ziekenhuis, locatie Groot Ziekengasthuis, 's-Hertogenbosch.
A 22-year-old man was admitted to the hospital with an ecstasy (MDMA) intoxication which was accompanied by hyperthermia. The patient developed rhabdomyolysis with hyperkalaemia, hypoglycaemia and acidosis, followed by multiple organ failure with disseminated intravascular coagulation and cerebral oedema. Despite maximal symptomatic treatment, the patient died after 4 days.
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