AI Article Synopsis
- A study compared 6% hydroxyethyl starch (HES) and 3% modified fluid gelatin (MFG) as volume replacement solutions in 46 patients undergoing major orthopedic hip surgery.
- Both solutions maintained stable hemodynamics and similar fluid and colloidal replacement volumes during the surgery, with no significant clinical differences in laboratory variables.
- The research concluded that both HES and MFG were effective and safe for use, adhering to the accepted maximum daily dosage guidelines in Germany and France.
Article Abstract
We have compared 6% hydroxyethyl starch (HES 200/0.5) with 3% modified fluid gelatin (MFG) for volume replacement in major orthopaedic surgery and studied the effects on haemodynamic state, colloid osmotic pressure, blood clotting and plasma homeostasis. Using a controlled, randomized, single-blind clinical design, we studied 46 consecutive patients undergoing major elective orthopaedic hip surgery. The two groups were comparable in age, body weight and duration of surgery. Patients were maintained haemodynamically stable using both HES and MFG over the entire study. Fluid balance and colloidal replacement volumes were comparable in both groups (median perioperative infusion volume: HES 2500 ml, MFG 2400 ml). Laboratory variables were not clinically different. We conclude that both colloidal solutions were comparable in volume efficacy and effects on plasma oncotic pressure, clotting and plasma homeostasis. In the small number of patients studied, 6% HES 200/0.5 was found to be safe when administered in amounts corresponding to the currently accepted maximum daily dose in Germany and France of 33 ml/kg body weight and 2.0 g/kg body weight, respectively.
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| http://dx.doi.org/10.1093/bja/78.1.44 | DOI Listing |
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