AI Article Synopsis
- The study examined the impact of carbamazepine on free and bound tryptophan levels in the plasma of 6 epileptic patients and 6 healthy volunteers over 7 days.
- The ratio of free to bound tryptophan decreased significantly in epileptic patients from day one, while healthy subjects only experienced this change after a week.
- These findings suggest that carbamazepine can alter amino acid levels in plasma, potentially affecting serotonin synthesis in the brain.
Article Abstract
The Authors estimated the influence of carbamazepine on both free and linked albumin triptofane in the plasma of 6 epileptic patients and of 6 healthy volunteers, during a period of observation lasting 7 days. The relation free/linked triptofane decreased significantly in the epileptic patients after the first day of treatment, while an analogous phenomenon was observed in healthy people only after the seventh day. Part of triptofane disappeared from plasma thus suggesting a cerebral uptake of the synthesis of serotonin. Carbamazepine displaced some unknown compounds from their links with plasmatic albumin, thus allowing triptofane to link itsel. The Authors therefore confirm the role played by anticonvulsive drugs in modifying the pool of free aminoacids in plasma.
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