We have sequenced a contiguous 284,495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend analysis of the primary sequence, we have characterized mRNA transcripts, patterns of DNA methylation and DNase I sensitivity. Together with previous data these studies describe in detail the structural and functional organization of a human telomeric region.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ng0397-252 | DOI Listing |
Publication Analysis
Top Keywords
human telomeric
8
telomeric region
8
relationship chromosome
4
chromosome structure
4
structure function
4
function human
4
region sequenced
4
sequenced contiguous
4
contiguous 284495-bp
4
284495-bp segment
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!