Background: Common etiopathogenic factors may explain the association of systemic sarcoidosis with inflammatory bowel disease.

Methods: We report two cases of such an association: one of sarcoidosis that developed 2 years after proctocolectomy for ulcerative colitis and one of sarcoidosis and Crohn's colitis. Factors like increased cellular immunity or circulating immunocomplexes or autoantibodies may have a role. Exogenous agents or familiarity may also be involved.

Conclusions: It is postulated that the association between sarcoidosis and inflammatory bowel disease (both ulcerative colitis and Crohn's disease) does not occur by chance alone and that the two conditions may share some genetic or immunologic alterations. The two diseases, however, follow an independent clinical course.

Download full-text PDF

Source
http://dx.doi.org/10.3109/00365529509101635DOI Listing

Publication Analysis

Top Keywords

inflammatory bowel
12
bowel disease
8
report cases
8
sarcoidosis inflammatory
8
association sarcoidosis
8
ulcerative colitis
8
sarcoidosis
5
association
4
association inflammatory
4
disease sarcoidosis
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!