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Temporomandibular Joint Disorders in Elderly Patients.
Cureus
January 2025
Department of Biology and Basic Subjects, Faculty of Dental Medicine, Hassan II University of Casablanca, Casablanca, MAR.
The management of temporomandibular disorders (TMDs) in elderly patients can present a significant challenge for dentists due to its multifactorial etiology, aging-related changes that contribute to TMD, and the fragile psychological state of these patients. Despite the growing prevalence of TMD in the elderly population, the scientific literature provides limited information about effective management strategies for this group. Therefore, it is crucial for researchers and clinicians to focus on improving our understanding of TMD in the elderly population and to develop more effective treatment approaches.
View Article and Find Full Text PDFNMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models.
Int J Mol Sci
November 2024
Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3103301, Israel.
N-methyl-D-aspartate receptors (NMDARs) are critical components of the mammalian central nervous system, involved in synaptic transmission, plasticity, and neurodevelopment. This review focuses on the structural and functional characteristics of NMDARs, with a particular emphasis on the GRIN2 subunits (GluN2A-D). The diversity of GRIN2 subunits, driven by alternative splicing and genetic variants, significantly impacts receptor function, synaptic localization, and disease manifestation.
View Article and Find Full Text PDFCurrent thinking in the management of temporomandibular disorders in children: A narrative review.
Br J Oral Maxillofac Surg
December 2024
Oral and Maxillofacial Surgery Department, Great Ormond Street Hospital, London, Greater London WC1N 3JH, UK.
Article Synopsis
- The narrative review focuses on the rise of pediatric temporomandibular disorders (TMDs) in maxillofacial clinics, highlighting the need for updated treatment approaches.
- It discusses key categories of TMD, including myogenous and arthogenous pain, juvenile idiopathic arthritis (JIA), and reconstruction, emphasizing the importance of psychosocial management and cautious medication use in children.
- Surgical interventions like arthroscopy are becoming more prevalent, but concerns remain regarding their effectiveness in preventing disease progression and achieving long-term success with joint replacements.
Evaluation of () as a Sample Adequacy Control in HPV Molecular Diagnostics.
Diagnostics (Basel)
September 2024
School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Article Synopsis
- * The research focused on evaluating sample cellularity using a specific gene target to ensure sample adequacy in HPV diagnostics.
- * Findings indicate that the gene target is an effective marker for assessing sample quality, reducing the likelihood of false-negative results in HPV testing.
Identifying phenotypes in persons with temporomandibular disorders, using latent class analyses: Temporomandibular disorders and phenotypes.
J Oral Rehabil
November 2024
Department of Interdisciplinary Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway.
Background: The heterogeneity of persons with temporomandibular disorders (TMD) and the lack of effective treatments have called for a biopsychosocial model and the development of a more personalised treatment approach. Emphasis on phenotypes might be a beneficial approach.
Objective: Identifying phenotypes among persons with TMD using potential prognostic factors, including personal characteristics and responses to clinical tests.
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