Recently, the involvement of EB virus in gastric cancer has drawn world-wide attention. In Japan, it is suspected that EB-virus is related to 5-10% of stomach cancer. In this paper, we briefly reviewed EBV-related immune responses and HLA distributions in EBV-related diseases. A brief description on our recent studies on the comparison of HLA distributions in EB-virus positive and negative stomach cancers was also given.
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