Nasopharyngeal carcinoma (NPC) is one of important problems of public health in the south of Asian countries and North Africa. The Epstein-Barr virus(EBV) is thought to be a key factor in this cancer as attested by several facts: the constant presence of the EBV genome in all malignant cells, the expression of several viral proteins with known oncogenic activity and the precession of serological modifications. Several proto-oncogenes were also activated in relation with viral gene expression. A possible presence of chromosome deletion in the region where some anti-oncogenes are localized, was also described. From these observations, future objective in NPC research will be to define whether EBV is a sole responsible factor in the development of NPC.
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Integrative Transcriptome-Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility.
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Nasopharyngeal carcinoma (NPC) is an Asia-prevalent malignancy, yet its genetic underpinnings remain incompletely understood. Here, a transcriptome-wide association study (TWAS) is conducted on NPC, leveraging gene expression prediction models based on epithelial tissues and genome-wide association study (GWAS) summary statistics from 1577 NPC cases and 6359 controls of southern Chinese descent. The TWAS identifies VAMP8 on chromosome 2p11.
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