FlyBase is a database of genetic and molecular data concerning Drosophila. FlyBase is maintained as a relational database (in Sybase) and is made available as html documents and flat files. The scope of FlyBase includes: genes, alleles (and phenotypes), aberrations, transposons, pointers to sequence data, clones, stock lists, Drosophila workers and bibliographic references. The Encyclopedia of Drosophila is a joint effort between FlyBase and the Berkeley Drosophila Genome Project which integrates FlyBase data with those from the BDGP.
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| http://dx.doi.org/10.1093/nar/25.1.63 | DOI Listing |
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Sex-specific viability effects of mutations in Drosophila melanogaster.
Evolution
October 2024
Department of Genetics, University of Wisconsin-Madison, 425-G Henry Mall, Madison, WI 53706, United States.
In populations with separate sexes, genetic load due to deleterious mutations may be expressed differently in males and females. Evidence from insect models suggests that selection against mutations is stronger in males. This pattern will reduce deleterious allele frequencies at the expense of males, such that female mean fitness is greater than expected, preserving population persistence in the face of high mutation rates.
View Article and Find Full Text PDFDrosophila kikkawai - Sox102F.
MicroPubl Biol
July 2024
Biology, New Jersey City University, Jersey City, New Jersey, United States.
Article Synopsis
- The feature with NCBI Gene ID 108084518 is identified as an ortholog of a member in the FlyBase High Mobility Group Box Transcription Factors gene group.
- Five isoforms were created using the GEP F element annotation method, with Sox102F-PNE being the longest and novel isoform based on specific RefSeq prediction and RNA-seq data.
- The longest isoform, Sox102F-PB, shows a 1.18x expansion in coding span due to the insertion of a transposable element in an intron, and all isoforms share the conserved HMG_box_dom domain.
An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research.
Cells
July 2024
Department of Biology, Indiana University, Bloomington, IN 47401, USA.
Studies on numerous species have demonstrated strikingly conserved mechanisms that determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The fruit fly is an excellent model organism for studying the biological basis of normal aging and etiology of age-related diseases. Since its inception in 1967, the Bloomington Drosophila Stock Center (BDSC) has grown into the largest collection of documented strains (currently > 91,000).
View Article and Find Full Text PDFThe alpha-ketoacid dehydrogenase complexes of .
MicroPubl Biol
April 2024
FlyBase, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, U.K.
The conserved family of alpha-ketoacid dehydrogenase complexes (AKDHCs) catalyze essential reactions in central metabolism and their dysregulation is implicated in several human diseases. provides an excellent model system to study the genetics and functions of these complexes. However, a systematic account of Drosophila AKDHCs and their composition has been lacking.
View Article and Find Full Text PDFComprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster.
Nucleic Acids Res
April 2024
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding of rRNA secondary structures and therefore in ribosomal function. Along with pseudouridine, methylation of the 2'-hydroxyl ribose moiety (Nm) is the most abundant modification of rRNAs. The majority of Nm modifications in eukaryotes are placed by Fibrillarin, a conserved methyltransferase belonging to a ribonucleoprotein complex guided by C/D box small nucleolar RNAs (C/D box snoRNAs).
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