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Pricing for Multi-Indication Drugs in the Italian Regulatory Context.
Pharmacoecon Open
January 2025
HTA & Pharmaceutical Economics Department, Italian Medicines Agency (AIFA), Rome, Italy.
Background: The authorization of new therapeutic indications for drugs already reimbursed by the Italian National Health Service (NHS) represents a matter of importance. This study aims to estimate the additional discount attributed to the extension of indications (EoIs) to explore the potential correlation between spending and negotiated discounts and to find specific factors (determinants) that impact on discount.
Methods: The study focused on drugs approved in Italy between 2003 and 2017 with at least four therapeutic indications, including the first approved and EoIs, with follow-up extended until 2021 to acquire all the information on the negotiation process that has been completed.
Meaningful change threshold estimation for the non-small cell lung cancer symptom assessment questionnaire (NSCLC-SAQ): psychometric analysis from a phase 3 trial (LIBRETTO-431).
Qual Life Res
January 2025
Adelphi Values, Adelphi Mill, Bollington, Cheshire, UK.
Purpose: Meaningful change thresholds are important to help interpret patient-reported outcome scores. To date, meaningful within-patient change (MWPC) thresholds have only been proposed for NSCLC-SAQ total score. This study proposed clinically MWPC thresholds, and group-level minimal important change/difference (MIC/MID) thresholds for both improvement and worsening for the Non-Small Cell Lung Cancer- Symptom Assessment Questionnaire (NSCLC-SAQ) total and symptom scores.
View Article and Find Full Text PDFCRISPR-Cas-mediated adaptation of Thermus thermophilus HB8 to environmental stress conditions.
Arch Microbiol
January 2025
Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden.
Bacteria experience a continual array of environmental stresses, necessitating adaptive mechanisms crucial for their survival. Thermophilic bacteria, such as Thermus thermophilus, face constant environmental challenges, particularly high temperatures, which requires robust adaptive mechanisms for survival. Studying these extremophiles provides valuable insights into the intricate molecular and physiological processes used by extremophiles to adapt and survive in harsh environments.
View Article and Find Full Text PDFEarly Meniscal Repair Leads to Higher Success Rates Than Delayed Meniscal Repair: A Systematic Review and Meta-analysis.
Am J Sports Med
January 2025
Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Background: There has been an increased interest in meniscus preservation over the last decade. Several risk factors for the failure of meniscal repair have been identified. However, the timing of meniscal repair has not been extensively assessed in the literature, and there is currently no high-quality evidence on the optimal timing of performing meniscal repair after an injury with regard to outcomes.
View Article and Find Full Text PDFThe Tinnitus Handicap Inventory Total Score: What Really Counts? Experience on a Sample of 1156 Patients.
Audiol Res
January 2025
ENT Division, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Background: Tinnitus is a frequent symptom, and is present in 10-15% of people who suffer from chronic tinnitus, defined as heard every day for at least 6 months. Among these, 1-2% develop a strong emotive reaction, anxiety, and depression, leading to poor quality of life.
Objectives: to evaluate the comorbidities in tinnitus sufferers.
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