AI Article Synopsis
- The study investigates how staphylococcal enterotoxin B (SEB) causes T cell anergy, revealing that B cells play a crucial role in maintaining this anergy.
- The findings indicate that the T cells of B cell-deficient mice can still proliferate when stimulated with SEB, suggesting that anergy can be reversed.
- Importantly, the results imply that the effects of SEB on T cell anergy are not due to anti-SEB antibodies or suppressive factors produced by B cells in the lab.
Article Abstract
The mechanisms involved in the maintenance of staphylococcal enterotoxin B (SEB)-induced T cell anergy are poorly understood. Here, we demonstrate that CD4+ T cell anergy induced by SEB treatment is under partial B cell control. This effect is not mediated by anti-SEB antibodies or any in vitro B cell-produced suppresser factor. At day 13 after SEB immunization, T cells from B cell-deficient mice proliferate upon in vitro stimulation with SEB. These results suggest that SEB-induced T cell anergy is reversible and that B cells have an important function in anergy maintenance in CD4+ T cells, both in vivo and in vitro.
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| http://dx.doi.org/10.1093/intimm/9.1.65 | DOI Listing |
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