Pleural and peritoneal effusion secondary to primary malignancy is a significant problem in the management of the cancer patient. Respiratory embarrassment and discomfort associated with the formation and collection of fluid in the chest and abdomen are among the most distressing symptoms encountered as a result of malignant disease. The guidelines for treatment should be based on respiratory symptoms, and with the understanding that the procedure is palliative. Both surgical and medical forms of treatment have been used. These include thoracostomy-tube drainage alone or with the instillation of antimicrobial agents. Pleurectomy is effective but should be reserved for situations in which conservative approaches have failed. Antitumor agents, such as nitrogen mustard, are effective but toxic. The mode of action of antineoplastic agents is related to their ability to cause pleural sclerosis and obliterate the pleural space. Systemic chemotherapy and external beam radiation are rarely effective. The intracavitary application of radioactive colloids has been used since 1945. Colloidal radioactive gold Au 198 has been replaced by the pure beta emitter, colloidal chromic phosphate P 32. Instillation of a colloidal suspension of radioactive phosphorus represents a significant and effective palliative therapeutic modality for malignant effusion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0001-2998(79)80042-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and In-Vitro Evaluation of Doxorubicin-Loaded Methacrylate Gelatin (GelMa)-Acrylamide Hydrogels for the Treatment of Malignant Pleural Mesothelioma.
Pharm Res
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
Article Synopsis
- The study focuses on malignant pleural mesothelioma (MPM), a serious lung cancer, and investigates a new method to deliver the chemotherapy drug Doxorubicin using a specially developed hydrogel, aiming to improve treatment efficacy.
- The hydrogel, which combines GelMa and acrylamide, shows promising physical properties such as quick gelling, high swelling, and easy injectability, while effectively releasing Dox over 12 days without compromising its effectiveness.
- In cell studies, the Dox-loaded hydrogels outperform plain Dox in reducing tumor growth, demonstrating significant potential for localized chemotherapy in treating MPM.
Neuritogenic glycosaminoglycan hydrogels promote functional recovery after severe traumatic brain injury.
J Neural Eng
June 2024
Regenerative Bioscience Center, University of Georgia, Athens, GA, United States of America.
Severe traumatic brain injury (sTBI) induced neuronal loss and brain atrophy contribute significantly to long-term disabilities. Brain extracellular matrix (ECM) associated chondroitin sulfate (CS) glycosaminoglycans promote neural stem cell (NSC) maintenance, and CS hydrogel implants have demonstrated the ability to enhance neuroprotection, in preclinical sTBI studies. However, the ability of neuritogenic chimeric peptide (CP) functionalized CS hydrogels in promoting functional recovery, after controlled cortical impact (CCI) and suction ablation (SA) induced sTBI, has not been previously demonstrated.
View Article and Find Full Text PDFStimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse.
Nat Commun
May 2024
Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that poses significant treatment challenges due to its invasive nature and compromised immune response, leading to treatment failures and tumor recurrence.
- Researchers developed a novel bacterium-hydrogel superstructure that targets and destroys residual GBM cells, enhancing immune responses to prevent postoperative relapse.
- The system utilizes engineered Salmonella vehicles combined with nanocapsules to stimulate an immune response and promote the recruitment of immune cells, showing promise for treating patients with GBM at high risk of recurrence.
Novel biomimetic macromolecules system for highly efficient lubrication, ROS scavenging and osteoarthritis treatment.
Colloids Surf B Biointerfaces
July 2024
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
The early stages of osteoarthritis (OA) in the joints are typically characterized by two key factors: the dysfunction of articular cartilage lubrication and inflammation resulting from the excessive production of reactive oxygen species (ROS). Synthetic injectable macromolecular materials present great potential for preventing the progression of early OA. In this study, to mimic the excellent lubricity of brush-like aggregates found in natural synovial fluid, we develop a novel macromolecular biolubricant (CS-PS-DA) by integrating adhesion and hydration groups onto backbone of natural biomacromolecules.
View Article and Find Full Text PDFFirst Local Experience of Intra-Cavitary Yttrium-90 Citrate Colloid Irradiation via Ommaya Reservoir for Refractory Cystic Craniopharyngioma: a Case Report.
Nucl Med Mol Imaging
May 2024
Department of Nuclear Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Craniopharyngioma is uncommon benign intracranial tumour that can be cured by surgical resection followed by conventional radiotherapy. However, its anatomical localisation makes the treatment hazardous or impossible. This case report aims to discuss the first local experience of using beta-emitting Yttrium-90 radioisotope in treating a patient with refractory cystic craniopharyngioma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!