Aminostigmin, a novel reversible inhibitor of cholinesterase developed in Russia, has been tried in management of poisoning with cholinolytyics, antihistamine drugs, tricycle antidepressants and derivatives of 1,4-benzodiazepine. The treatment of 144 patients with aminostigmin and 20 patients with galantamin showed close to similar efficacy of these drugs. The scheme of aminostigmin administration is proposed warranting fast relief of cholinolytic syndrome in subjects poisoned with cholinolytics, antihistamine drugs and antidepressants. Benzodiazepines poisoning was unresponsive to aminostigmin. Rare side effects were caused by overdose. Aminostigmin is an effective antidote in cholinolytic poisoning.
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