[Hemostasis disorders after resection of liver and approaches to their prevention and correction].

Second- or third-degree dysfunction of hepatocytes was the most frequent (47.9%) disorder in the hemostasis system on the first-second days after extensive resection of the liver, whereas after economic resection this disorder was observed in only 5.5% patients. Intraoperative blood loss of more than 3 liters is fraught with hemorrhages and hepatorenal insufficiency in the postoperative period. Such blood loss is complicated by coagulopathic states presenting as 1) hepatocyte dysfunction of the second-third degree, 2) hypoxia and decreased production of blood clotting factors, and 3) variants of the DIC syndrome. Study of the genesis of postoperative coagulopathies after resection of the liver and development of pathogenetically-based methods of drug correction, together with introduction of novel instrumental methods affecting the intensity of local and total hemostatic reaction, helped reduce 2.5 to 3 times the total blood loss.