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Energy of Functional Brain States Correlates With Cognition in Adolescent-Onset Schizophrenia and Healthy Persons.
Hum Brain Mapp
January 2025
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Adolescent-onset schizophrenia (AOS) is relatively rare, under-studied, and associated with more severe cognitive impairments and poorer outcomes than adult-onset schizophrenia. Neuroimaging has shown altered regional activations (first-order effects) and functional connectivity (second-order effects) in AOS compared to controls. The pairwise maximum entropy model (MEM) integrates first- and second-order factors into a single quantity called energy, which is inversely related to probability of occurrence of brain activity patterns.
View Article and Find Full Text PDFContemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocrit Care
January 2025
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Background: Neuroleptic malignant syndrome (NMS) is a psychiatric-neurologic emergency that may require intensive care management. There is a paucity of information about NMS as a critical illness. We reviewed the Mayo Clinic experience.
View Article and Find Full Text PDFMood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study.
Ann Gen Psychiatry
December 2024
Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South University, Changsha, China.
Article Synopsis
- Mood instability involves sudden mood changes and is linked to psychiatric disorders and gastrointestinal issues, though the causal relationship is not well understood.
- Researchers conducted Mendelian randomization analysis using genetic data to explore this relationship, examining mood instability alongside 28 gastrointestinal diseases.
- Results indicated that mood instability is genetically related to several gastrointestinal diseases even after accounting for other mental health conditions, suggesting it may be a significant risk factor for these illnesses.
Is there a relationship between psychiatrist's clinical assessment of medication non-adherence and treatment outcomes? Implications for practice.
BMC Psychiatry
December 2024
John George Psychiatric Hospital, 2060, Fairmont Drive, San Leandro, CA, 94578, USA.
Background: There is considerable research on the ramifications of medication non-adherence for adults with psychotic illnesses. Much of which has tightly controlled designs and strict inclusion/exclusion procedures (i.e.
View Article and Find Full Text PDFReconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies.
Mol Psychiatry
November 2024
Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, 2, Chemin du Petit-Bel-Air, CH-1226, Thonex, Switzerland.
Background: Persons with schizophrenia are excluded from psychedelic-assisted therapy due to concerns about the risk of triggering or worsening psychosis. However, there is limited meta-analytic data on the risk of psychedelic-induced psychosis in individuals with pre-existing psychotic disorders.
Methods: We conducted a systematic review, meta-analysis, and overview of reviews to assess the incidence of psychedelic-induced psychosis and symptom exacerbation in schizophrenia.
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