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Dermoscopic Examination of Tinea Nigra on the Plantar Foot Unveils a Parallel Ridge Pattern Mimicking Acral-Lentiginous Melanoma.
Med Mycol J
December 2024
Department of Dermatology, Juntendo University Urayasu Hospital.
A man in his thirties patient visited his previous physician with the chief complaint of a pigmented macule on the sole of his left foot that had steadily grown over the past two years. A dermoscopic examination of the lesion showed a parallel ridge pattern (PRP); therefore, acral-lentiginous melanoma (ALM) was suspected, and the patient was referred to our hospital for a more detailed examination. On closer inspection, PRP had a well-defined and irregular border with no variation in color, which is atypical for ALM which is characterized by asymmetrical structure and variation in colors.
View Article and Find Full Text PDFNiosomal gel improves dermal delivery of nimbolide: a promising approach for treatment of psoriasis.
Nanomedicine (Lond)
December 2024
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.
Psoriasis is a chronic inflammatory skin disorder characterized by the excessive proliferation of keratinocytes, forming thickened skin plaques due to immune-mediated cytokine responses. Delivering drugs through this barrier to target inflamed tissues remains challenging. Nimbolide (NIM), known for its anti-inflammatory and anticancer properties, shows promise in managing psoriasis.
View Article and Find Full Text PDFCoincidence of acral peeling skin syndrome and Nagashima-type palmoplantar keratosis in a Japanese pedigree with acral skin peeling.
J Dermatol
August 2024
Department of Dermatology, Self-Defense Forces Central Hospital, Tokyo, Japan.
Acral peeling skin syndrome (APSS; MIM 609796) is a rare genodermatosis characterized by painless focal cutaneous exfoliation of the dorsal hands and feet, typically displaying autosomal recessive inheritance. While cases associated with a founder mutation in TGM5 are relatively common in European Caucasian populations, no APSS cases have been reported from Japan or other East Asian countries. In contrast, Nagashima-type palmoplantar keratosis (NPPK; MIM 615598), caused by variants in SERPINB7, is relatively common in East Asia due to founder mutations.
View Article and Find Full Text PDFPorokeratoses: an update on pathogenesis and treatment.
Int J Dermatol
January 2025
Department of Dermatology, Edouard Herriot Hospital, Lyon, France.
Article Synopsis
- Porokeratoses (PK) are rare skin conditions caused by issues with the mevalonate metabolic pathway, showing various subtypes that can manifest in the same individual or family.
- All PK subtypes exhibit a unique histopathological feature known as the cornoid lamella and are more severe in immunosuppressed patients, with their development linked to specific gene mutations requiring a secondary triggering event.
- Treatment options have historically included physical and topical methods with mixed success, but new therapies targeting the metabolic pathway, like statins combined with cholesterol, show greater effectiveness, despite some cases remaining difficult to manage.
New Skin-Relevant Cell Coculture Model With Stratum Corneum-Like Layer.
Biomed Res Int
June 2024
Department of Dermatological Research Sunny BioDiscovery Inc., 972 E. Main Street, Santa Paula, California, USA.
Two-dimensional (2D) cell culture is an important tool in the discovery of skin-active agents. Fibroblasts and keratinocytes, more rarely fibroblast-keratinocyte cocultures, are usually used for that purpose, where test compounds are added by mixing with the overlaying growth medium. However, such an approach is suboptimal because it lacks the component.
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