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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study.
Respir Res
January 2025
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.
Background: Lipoid pneumonia (LP) is a rare disease caused by the accumulation of lipids and lipid-laden macrophages in the alveoli inducing damage. LP is difficult to differentiate from other similar diseases without pathological evidence, such as upper respiratory tract infection (URTI), pneumonia, cryptogenic organizing pneumonia (COP), pulmonary alveolar proteinosis (PAP), lung mucinous adenocarcinoma and pulmonary edema. Given the high misdiagnosis rate and limited statistical clinical and treatment data, there is an urgent need for novel indicators of LP.
View Article and Find Full Text PDFLipid-laden macrophage index as a marker of aspiration in children, is it reliable? A scoping review.
Int J Pediatr Otorhinolaryngol
November 2024
Division of Pediatric Otolaryngology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada; McGill Otolaryngology Sciences Laboratory, Department of Pediatric Surgery, McGill University, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada. Electronic address:
Introduction: A diagnostic pathway to detect aspiration is challenging and usually requires a multidisciplinary approach and a variety of tests. Lipid-laden macrophage index (LLMI) was first described in 1985 by Corwin and Irwin as a promising tool to detect aspiration. Information in the literature as well as physicians' opinions about the clinical value of the LLMI remains controversial.
View Article and Find Full Text PDFLipid-Laden Macrophages in Pulmonary Diseases.
Cells
May 2024
Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Pulmonary surfactants play a crucial role in managing lung lipid metabolism, and dysregulation of this process is evident in various lung diseases. Alternations in lipid metabolism lead to pulmonary surfactant damage, resulting in hyperlipidemia in response to lung injury. Lung macrophages are responsible for recycling damaged lipid droplets to maintain lipid homeostasis.
View Article and Find Full Text PDFLipoid pneumonia induced by aspiration of liquid paraffin.
Ann Agric Environ Med
March 2024
Second Department of Radiology, Clinical Centre, Medical University, Gdańsk, Poland.
Article Synopsis
- This case report discusses a rare condition called exogenous lipoid pneumonia (ELP), which happens when lipid substances are inhaled, leading to inflammation in the lungs.
- The patient was an 83-year-old woman who used paraffin oil as a mouthwash over a long period, which contributed to her condition.
- Diagnosis of ELP was confirmed through her medical history, specific imaging results, and tissue analysis.
Polyhexamethylene guanidine accelerates the macrophage foamy formation mediated pulmonary fibrosis.
Ecotoxicol Environ Saf
March 2024
Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266000, China; Department of Environmental and Occupational Health, School of Public Health, Qingdao University, Qingdao 266071, China. Electronic address:
Polyhexamethylene guanidine (PHMG) is manufactured and applied extensively due to its superior disinfectant capabilities. However, the inhalatory exposure to PHMG aerosols is increasingly recognized as a potential instigator of pulmonary fibrosis, prompting an urgent call for elucidation of the underlying pathophysiological mechanisms. Within this context, alveolar macrophages play a pivotal role in the primary immune defense in the respiratory tract.
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