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Supramolecular Partners: Precision On/Off Neuromuscular Blockage for Prolonged Surgeries.
J Med Chem
March 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, & Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China.
The development of a long-acting neuromuscular blocking agent and its on-demand reversal is highly desired for prolonged surgeries. This viewpoint discussed the discovery of supramolecular partners, an imidazolium-based macrocycle (YW70271) and acyclic cucurbit[n]uril (WY22051), for ultralong neuromuscular blockade and rapid reversal.
View Article and Find Full Text PDFBackground: Inherited rare skeletal muscle diseases cause muscle weakness and wasting of variable severity. Without a molecular diagnosis, patients often endure prolonged diagnostic journeys, leading to delays in appropriate management of the disease. This occurs in approximately 60% of patients with rare diseases.
View Article and Find Full Text PDFPeripheral immune profiling highlights a dynamic role of low-density granulocytes in myasthenia gravis.
J Autoimmun
March 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disease marked by dysregulation of several immune cell populations. Here we explored peripheral immune landscape, particularly the role of low-density granulocytes (LDGs).
Methods: Single-cell and bulk RNA sequencing analyzed peripheral immune cells from MG patients pre- (n = 4) and after treatment (n = 2), as well as healthy controls (n = 3).
Effect of single-dose intravenous lignocaine versus fentanyl on neuromuscular recovery time after general anesthesia in elective pediatric surgery: A randomized controlled pilot study.
J Anaesthesiol Clin Pharmacol
May 2024
Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Background And Aims: Intravenous (IV) lignocaine is often used to prevent the airway response to extubation, especially in children to prevent respiratory adverse events. It is known to prolong the duration of action of neuromuscular blocking drugs, but data in children are limited. The primary objective of this study was to compare neuromuscular recovery time with IV lignocaine versus fentanyl, in pediatric patients undergoing elective surgery under general anesthesia (GA).
View Article and Find Full Text PDFPrevalence of hospital-acquired infection among patients with acute neurological conditions in the ICU.
J Clin Neurosci
April 2025
Department of Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Introduction: Healthcare-associated infections (HAIs) are a significant cause of morbidity and mortality. HAIs become crucial in patients with neurological illnesses, as they need invasive procedures and extended care, prolonging the hospital stay in most cases. In this study, we report the type, microbial etiology, and outcome of patients with HAIs in a Neurology Intensive Care Unit setting.
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