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PRMT5 Inhibitor EPZ015666 Decreases the Viability and Encystment of .
Molecules
December 2024
Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, Mexico.
Protein arginine methyltransferase 5 (PRMT5) is an enzyme that produces monomethyl arginine (MMA) and symmetric dimethyl arginine (sDMA), post-translational modifications that regulate several cellular processes, including stage conversion in parasitic protozoans. , the etiologic agent of human amebiasis, has two stages in its life cycle, the trophozoite, which is the replicative form, and the cyst, corresponding to the infective phase. The study of the molecular mechanisms that regulate differentiation in this parasite has been overdue because of a lack of efficient protocols for in vitro encystment.
View Article and Find Full Text PDFIdentification of two transcription factors that work coordinately to regulate early development in .
mBio
December 2024
Division of Infectious Diseases, Stanford University School of Medicine, Palo Alto, California, USA.
The protozoan parasite has a life cycle that switches between infective cysts and invasive trophozoites. Encystation, a crucial process in parasite biology, is controlled by different mechanisms including transcriptional control. We identified two nuclear proteins in , EIN_066100 and EIN_085620, that regulate parasite development by binding to a DNA motif (TCACTTTC) in the promoter regions of genes upregulated in the first 8 h of stage conversion.
View Article and Find Full Text PDFExploration of the Binding Site of Arachidonic Acid in gp63 of and in Orthologous Proteins in Clinically Important Parasites.
Pathogens
August 2024
Departamento de Infectómica y Patogénesis Molecular, CINVESTAV, Av. IPN No. 2508, Col. San Pedro Zacatenco, México City 07360, Mexico.
Recently, we published that the monoclonal antibody (D12 mAb) recognizes gp63 of , and it is responsible for COX activity. This D12 mAb exhibited cross-reactivity with , , , and . COX activity assays performed in these parasites suggested the potential presence of such enzymatic activity.
View Article and Find Full Text PDFAncestral TALE homeobox protein transcription factor regulates actin dynamics and cellular activities of protozoan parasite Entamoeba invadens.
Mol Microbiol
November 2024
Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Entamoeba histolytica causes invasive amoebiasis, an important neglected tropical disease with a significant global health impact. The pathogenicity and survival of E. histolytica and its reptilian equivalent, Entamoeba invadens, relies on its ability to exhibit efficient motility, evade host immune responses, and exploit host resources, all of which are governed by the actin cytoskeleton remodeling.
View Article and Find Full Text PDFGenome-Wide Classification of Myb Domain-Containing Protein Families in .
Genes (Basel)
February 2024
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City C.P. 03100, Mexico.
Article Synopsis
- The study investigates the role of Myb proteins in the encystation process of the parasite causing amebiasis, a leading cause of death from parasitic diseases.
- Researchers identified 48 MYB-domain-containing genes, classifying them into different types based on their structure, indicating their multifunctional roles in various cellular processes like transcription regulation and chromatin remodeling.
- The findings point to Myb proteins' involvement in regulating genes needed for encystation and other cellular functions, laying the groundwork for future research into treatment options for amebiasis.
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