Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1385/0-89603-483-6:405 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.
Biochem Biophys Res Commun
January 2025
Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200433, China. Electronic address:
Objective: Gliomas pose a significant global health challenge due to high rates of morbidity and mortality. Recent research has indicated that circular RNAs (circRNAs) may play a crucial role in gliomas. However, the specific impacts of circRNAs on gliomas development is poorly understood.
View Article and Find Full Text PDFPhotochemical regulation of microcystin synthesis and release in cyanobacteria Microcystis aeruginosa by triplet state dissolved organic matter.
Sci Total Environ
January 2025
College of Environment and Ecology, Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing, 400045, China. Electronic address:
The increasing frequency of cyanobacterial blooms, particularly those induced by Microcystis aeruginosa (M. aeruginosa), poses severe economic, ecological and health challenges due to the production of microcystins (MCs). Environmental parameters such as light and nutrient availability influence MCs production, while the role of dissolved organic matter (DOM) photochemical processes in regulating these remains unclear.
View Article and Find Full Text PDFIdentification of SETD4 as an Onco-Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers.
Immun Inflamm Dis
January 2025
Second Department of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Background: SET domain-containing protein 4 (SETD4) is a histone methyltransferase that has been shown to modulate cell proliferation, differentiation, and inflammatory responses by regulating histone H4 trimethylation (H4K20me3). Previous reports have demonstrated its function in the quiescence of cancer stem cells as well as drug resistance in several cancers. A limited number of systematic studies have examined SETD4's role in the tumor microenvironment, pathogenesis, prognosis, and therapeutic response.
View Article and Find Full Text PDFInterleukin-17A facilitates tumor progression upregulating programmed death ligand-1 expression in hepatocellular carcinoma.
World J Gastrointest Oncol
January 2025
The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Background: Hepatocellular carcinoma (HCC) is an inflammation-associated tumor with a dismal prognosis. Immunotherapy has become an important treatment strategy for HCC, as immunity is closely related to inflammation in the tumor microenvironment. Inflammation regulates the expression of programmed death ligand-1 (PD-L1) in the immunosuppressive tumor microenvironment and affects immunotherapy efficacy.
View Article and Find Full Text PDFMachine learning-based pan-cancer study of classification and mechanism of BRAF inhibitor resistance.
Transl Cancer Res
December 2024
Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Background: V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitor (BRAFi) therapy resistance affects approximately 15% of cancer patients, leading to disease recurrence and poor prognosis. The aim of the study was to develop a machine-learning based method to identify patients who are at high-risk of BRAFi resistance and potential biomarker.
Methods: From Cancer Cell Line Encyclopedia (CCLE) and Genomics of Drug Sensitivity in Cancer (GDSC) databases, we collected RNA sequencing and half maximal inhibitory concentration (IC) data from 235 pan-cancer cell lines and then identified 37 significant differential expression genes associated with BRAFi resistance.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!