Neurones immunoreactive for vasoactive intestinal polypeptide (VIP) were studied in monkey medial prefrontal cortex. The majority (78.0%) of VIP+ neurones were bipolar cells located mainly in layers 2/3. Calretinin (CR) immunoreactivity was colocalised in 80.5% of VIP+ neurones. Furthermore, VIP+ puncta formed pericellular baskets around GABA immunonegative somata in layers 2/3. These results indicate that VIP/CR are colocalised in some bipolar cells and superficial pyramidal somata are likely targets of VIP+ neurones.
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