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Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review.
J Clin Med
September 2023
Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Long-term medication with valproic acid has been associated with acute pancreatitis. The purpose of this report is to gain insight into the features of this pancreatitis. A preregistered literature search (CRD42023438294) was performed on the National Library of Medicine, Excerpta Medica, Web of Science, and Google Scholar.
View Article and Find Full Text PDFValproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case.
Cureus
August 2015
Surgical Gastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research.
Valproic acid is the most widely used anti-epilep-tic drug in children, and it is probably the most frequent cause of drug-induced acute pancreatitis. Outcomes for patients with valproic acid-associated pancreatitis vary from full recovery after discontinuation of the drug to severe acute pancreatitis and death. Here, we present a case of valproic acid-induced severe acute pancreatitis with pseudocyst formation in a 10-year-old girl with cerebral palsy and generalized tonic-clonic seizure.
View Article and Find Full Text PDFNovel characterization of drug-associated pancreatitis in children.
J Pediatr Gastroenterol Nutr
October 2011
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
Background And Objectives: Medications are a major cause of acute pancreatitis; however, little is known about their influence in children. Our primary aims were to identify common comorbidities and concomitant pancreatitis etiologies in children with drug-associated pancreatitis. Our secondary aims were to identify the most commonly associated drugs in the different age groups, evaluate management practices, and compare drug-associated cases with non-drug-associated cases.
View Article and Find Full Text PDFThe spectrum of valproic acid-associated pancreatitis.
Pediatrics
October 2006
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
Objective: Our goal was to characterize valproic acid-associated pancreatitis in children.
Patients And Methods: The charts of all patients with pancreatitis (diagnosed by using strict criteria) associated with valproic acid during a 10-year period were reviewed. Clinical and laboratory results were abstracted.
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