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Endovascular salvage of renal artery bypass in pediatric a patient with neurofibromatosis type 1.
J Vasc Surg Cases Innov Tech
February 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Neurofibromatosis type 1 (NF1) is a congenital vasculopathy that can affect the renal arteries, causing renovascular hypertension. We report a complex case of a pediatric NF1 patient who required endovascular salvage of a renal artery bypass. Treatment for pediatric renovascular NF1 requires close surveillance and the ability to pivot to rescue therapies.
View Article and Find Full Text PDFVascular Abnormalities and Neurofibromatosis Type 1: A Paediatric Case Series.
J Child Neurol
January 2025
Pediatric Clinic, "Microcitemico - A. Cao" Pediatric Hospital, University of Cagliari, Cagliari, Italy.
Article Synopsis
- - Neurofibromatosis type 1 (NF1) is a genetic disorder caused by a mutation that leads to issues like vascular and neurological abnormalities.
- - Serious complications can include moyamoya syndrome, which causes the progressive narrowing of brain arteries, and renal artery stenosis, a common cause of high blood pressure in NF1 patients.
- - The article reviews clinical cases of NF1 vasculopathy, focusing on diagnosis, management, and potential future strategies for screening and treatment options.
Renal Autotransplantation for Uncontrolled Hypertension in Nonatherosclerotic Renal Artery Stenosis-2 Case Reports and a Brief Review of the Literature.
Hypertension
April 2024
Department of Clinical Pharmacology and Therapeutics (J.G., S.K., V.S., I.B.W.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.
Article Synopsis
- Fibromuscular dysplasia is a leading cause of high blood pressure in young adults under 40, and renal artery angioplasty often helps normalize blood pressure.
- Two cases are discussed where patients with hypertension due to renal artery stenosis faced challenges: one had a relapse of stenosis after angioplasty, while the other couldn't undergo the procedure at all.
- Both patients ultimately received successful renal autotransplantations that resolved their high blood pressure, with the article also detailing relevant background and outcomes related to this surgical option.
"Tardus-parvus waveform" the only initial clue to mid-aortic syndrome- a rare cause of youth onset hypertension: A case report and a comprehensive review.
Radiol Case Rep
February 2024
Department of Radiology, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal.
Middle aortic syndrome (MAS), an uncommon cause of secondary hypertension, is defined by obstructive narrowing of the abdominal aorta and ostia of its major branches like the renal and splanchnic arteries. Most of the cases of MAS are categorized as idiopathic; however, genetic disorders like Williams syndrome, mucopolysaccharidosis, neurofibromatosis type 1 (NF1), and Alagille syndrome, and acquired inflammatory diseases such as Takayasu arteritis and other nonspecific arteritis can also lead to MAS. MAS is commonly seen in children and young adults presenting with severe hypertension, congestive heart failure, renal failure, or severe leg claudication.
View Article and Find Full Text PDFMalignant arterial hypertension in a 2-month-old girl: Etiological diagnosis and treatment.
Arch Pediatr
October 2022
CHU Robert-Debré, Hôpital Universitaire Mère-enfant Robert-Debré, 48 boulevard Sérurier, 75019, Paris, France.
A 2-month-old girl presented with malignant arterial hypertension revealing bilateral renal artery stenosis secondary to neurofibromatosis type 1 (NF1). Life-supporting care was initiated immediately. High-dose peripheral vasodilator therapy induced life-threatening toxicity; vascular surgery was therefore performed.
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