By using spectrochromatography the dioxidine and quinoxidine passage with urine, depending upon their doses and the method of introduction, was studied in tests on mice. On its enteral or subcutaneous introduction dioxidine is found in the urine within a period of 7-to 24 hours (depending upon the dose administered). With its maximum concentration it is definable within 1 hour. The animals' urine showed no presence of quinoxidine. In mice receiving quinoxidine the urine is found to contain the product of its disacetylization-dioxidine. The dynamics of the dioxidine excretion with urine in mice receiving quinoxidine is in line with regularities common to the passage of dioxidine following its administration to mice.
Download full-text PDF |
Source |
---|
Vestn Otorinolaringol
May 1998
Biocompatible polymeric endoprostheses EFOS are offered for endoprosthetic reconstruction of the external acoustic meatus in atresia. Such endoprostheses are safe for the adjacent tissues. Moreover, such prostheses contain antibacterial drugs (quinoxidine, dioxidin) and substances promoting tissue regeneration (orotic acid derivatives).
View Article and Find Full Text PDFTo estimate the in vitro susceptibility of the plague microbe to chemotherapeutics, various experimental models with the maximum closeness to the host conditions were tested. The tests included the assay of the drug antibacterial activity against the plague microbe by the method of two-fold dilutions in biological fluids i.e.
View Article and Find Full Text PDFThe authors present pilot experience of extranasal radical operations on the frontal sinuses with the use of polymeric tube endoprostheses made of biocompatible polymeric materials EFOS 1, 2, 3 containing antimicrobial drugs (dioxidin, chinoxidin) and active substances promoting regeneration and epithelization (orotic acid derivatives). The above technique was employed in operations on frontal sinuses in 12 patients. Polymeric endoprostheses EFOS provide adequate lumen of the formed frontonasal anastomosis, reduce the occurrence of postoperative complications and recurrences as well as hospital stay.
View Article and Find Full Text PDFAntibiot Khimioter
November 1991
The antimicrobial activity of capromed, a surgical polymer-coated sutural material containing dioxidine, quinoxidine or gentamicin was studied in vitro and in vivo. Capromed was shown to be active against the hospital strains of S. aureus, E.
View Article and Find Full Text PDFA new native synthetic absorbable antibacterial polyamide thread "Capromed DC" was used for liquidation of the abdominal wall defect in operation for postoperative recurrent hernia. The low incidence of complications caused by infection around the non-absorbable ligature was noted.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!